GO ID Total Under Over Change P-Value Term 45735 1 0 0 0 1 nutrient reservoir activity 15085 5 0 0 1 1 calcium ion transporter activity 15082 11 0 0 2 1 "di-, tri-valent inorganic cation transporter activity" 15081 11 0 0 7 0.001 sodium ion transporter activity 15078 70 0 0 40 0 hydrogen ion transporter activity 15077 71 0 0 40 0 monovalent inorganic cation transporter activity 15075 145 0 0 47 0 ion transporter activity 15071 8 0 0 3 0.1608 protein phosphatase type 2C activity 15070 4 0 0 0 1 toxin activity 15068 1 0 0 0 1 glycine amidinotransferase activity 15067 1 0 0 0 1 amidinotransferase activity 15057 3 0 0 0 1 thrombin receptor activity 15056 1 0 0 0 1 corticotrophin-releasing factor receptor activity 15055 1 0 0 0 1 secretin receptor activity 15054 1 0 0 0 1 gastrin receptor activity 15038 1 0 0 0 1 glutathione disulfide oxidoreductase activity 15037 1 0 0 0 1 peptide disulfide oxidoreductase activity 15036 12 0 0 4 0.2472 disulfide oxidoreductase activity 15035 3 0 0 2 0.0855 protein disulfide oxidoreductase activity 15034 8 0 0 0 1 cytochrome P450 activity 15027 3 0 0 0 1 "coreceptor, soluble ligand activity" 15026 6 0 0 0 1 coreceptor activity 15020 5 0 0 1 0.0507 glucuronosyltransferase activity 15018 2 0 0 0 1 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity 15002 12 0 0 9 0 heme-copper terminal oxidase activity 46030 2 0 0 0 1 inositol trisphosphate phosphatase activity 45523 1 0 0 0 1 interleukin-27 receptor binding 19239 11 0 0 1 0.701 deaminase activity 19238 3 0 0 1 0.4488 cyclohydrolase activity 19237 1 0 0 0 1 centromeric DNA binding 19214 3 0 0 0 1 surfactant activity 19212 4 0 0 1 0.5481 phosphatase inhibitor activity 19210 14 0 0 1 0.4878 kinase inhibitor activity 19209 2 0 0 0 1 kinase activator activity 19208 5 0 0 2 0.2224 phosphatase regulator activity 19207 54 0 0 10 0.8599 kinase regulator activity 19206 6 0 0 0 1 nucleoside kinase activity 19205 25 0 0 6 0.4336 "nucleobase, nucleoside, nucleotide kinase activity" 19203 6 0 0 0 1 carbohydrate phosphatase activity 19202 2 0 0 1 0.3277 amino acid kinase activity 19201 11 0 0 3 0.429 nucleotide kinase activity 19200 15 0 0 4 0.329 carbohydrate kinase activity 19199 54 0 0 6 0.2159 transmembrane receptor protein kinase activity 19198 1 0 0 1 0.18 transmembrane receptor protein phosphatase activity 19166 1 0 0 0 1 trans-2-enoyl-CoA reductase (NADPH) activity 19145 1 0 0 1 0.18 aminobutyraldehyde dehydrogenase activity 19136 4 0 0 0 1 deoxynucleoside kinase activity 19120 3 0 0 0 1 "hydrolase activity, acting on acid halide bonds, in C-halide compounds" 19107 2 0 0 0 1 myristoyltransferase activity 19104 6 0 0 0 1 DNA N-glycosylase activity 45309 1 0 0 0 1 phosphoprotein amino acid binding 45308 2 0 0 0 1 protein amino acid binding 1758 2 0 0 0 1 retinal dehydrogenase activity 19007 1 0 0 1 0.18 N-acetylneuraminic acid phosphate synthase activity 19002 5 0 0 0 1 GMP binding 19001 179 0 0 48 0.003 guanyl nucleotide binding 1734 1 0 0 0 1 mRNA (N6-adenosine)-methyltransferase activity 1729 1 0 0 0 1 ceramide kinase activity 1727 16 0 0 0 1 lipid kinase activity 1691 1 0 0 0 1 pseudophosphatase activity 1668 1 0 0 0 1 "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity" 1664 29 0 0 4 0.8079 G-protein-coupled receptor binding 1653 77 0 0 2 0.0001 peptide receptor activity 1642 4 0 0 0 1 group III metabotropic glutamate receptor activity 1641 2 0 0 0 1 group II metabotropic glutamate receptor activity 1640 6 0 0 0 1 adenylate cyclase inhibiting metabotropic glutamate receptor activity 1639 2 0 0 0 1 PLC activating metabotropic glutamate receptor activity 1637 18 0 0 0 1 G-protein chemoattractant receptor activity 1636 1 0 0 0 1 corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity 1633 15 0 0 0 1 secretin-like receptor activity 1631 1 0 0 0 1 cysteinyl leukotriene receptor activity 1619 7 0 0 0 1 lysosphingolipid and lysophosphatidic acid receptor activity 1616 1 0 0 0 1 growth hormone secretagogue receptor activity 1615 2 0 0 0 1 thyrotropin releasing hormone and secretagogue-like receptors activity 1614 34 0 0 0 1 purinergic nucleotide receptor activity 1613 1 0 0 0 1 "A3 adenosine receptor activity, G-protein coupled" 1612 1 0 0 0 1 "A2B adenosine receptor activity, G-protein coupled" 1611 1 0 0 0 1 "A2A adenosine receptor activity, G-protein coupled" 1610 1 0 0 0 1 "A1 adenosine receptor activity, G-protein coupled" 1609 4 0 0 0 1 "adenosine receptor activity, G-protein coupled" 1608 34 0 0 0 1 "nucleotide receptor activity, G-protein coupled" 1607 1 0 0 0 1 neuromedin U receptor activity 1603 4 0 0 1 0.5481 vasopressin-like receptor activity 1602 3 0 0 0 1 pancreatic polypeptide receptor activity 1601 5 0 0 0 1 peptide YY receptor activity 1600 1 0 0 0 1 endothelin-B receptor activity 45182 221 0 0 46 0.2848 translation regulator activity 45127 1 0 0 0 1 N-acetylglucosamine kinase activity 45125 8 0 0 0 1 bioactive lipid receptor activity 1595 3 0 0 0 1 angiotensin receptor activity 1591 1 0 0 0 1 dopamine D2 receptor-like receptor activity 1584 171 0 0 2 0 rhodopsin-like receptor activity 1565 2 0 0 0 1 phorbol ester receptor activity 1540 2 0 0 0 1 beta-amyloid binding 1537 1 0 0 0 1 N-acetylgalactosamine-4-O-sulfotransferase activity 1530 1 0 0 0 1 lipopolysaccharide binding 1524 1 0 0 0 1 globin 1515 2 0 0 0 1 opioid peptide activity 1509 2 0 0 0 1 legumain activity 45028 34 0 0 0 1 "purinergic nucleotide receptor activity, G-protein coupled" 45012 1 0 0 0 1 MHC class II receptor activity 18271 1 0 0 0 1 biotin-protein ligase activity 18024 2 0 0 1 0.3277 histone-lysine N-methyltransferase activity 739 1 0 0 0 1 DNA strand annealing activity 702 1 0 0 0 1 oxidized base lesion DNA N-glycosylase activity 5554 393 0 0 89 0.0176 molecular_function unknown 5548 3 0 0 0 1 phospholipid transporter activity 5545 2 0 0 1 0.3277 phosphatidylinositol binding 5544 14 0 0 8 0.0012 calcium-dependent phospholipid binding 5543 20 0 0 9 0.0048 phospholipid binding 5542 7 0 0 0 1 folic acid binding 5541 21 0 0 3 1 acyl-CoA or acyl binding 5540 11 0 0 1 0.701 hyaluronic acid binding 5539 46 0 0 6 0.4467 glycosaminoglycan binding 5537 2 0 0 0 1 mannose binding 5536 1 0 0 0 1 glucose binding 5531 3 0 0 0 1 galactose binding lectin 5530 1 0 0 0 1 lectin 5529 42 0 0 0 1 sugar binding 5528 4 0 0 1 0.5481 FK506 binding 5527 4 0 0 1 0.5481 macrolide binding 5525 138 0 0 42 0.0003 GTP binding 5524 880 0 0 167 0.423 ATP binding 5523 5 0 0 0 1 tropomyosin binding 5522 4 0 0 0 1 profilin binding 5520 17 0 0 5 0.2115 insulin-like growth factor binding 5519 1 0 0 0 1 cytoskeletal regulatory protein binding 5518 2 0 0 0 1 collagen binding 5516 55 0 0 3 0.0124 calmodulin binding 5515 825 0 0 149 0.9614 protein binding 5514 5 0 0 2 0.2224 calcium ion storage activity 5509 290 0 0 53 0.876 calcium ion binding 5507 26 0 0 7 0.3013 copper ion binding 5506 18 0 0 2 0.7572 iron ion binding 5505 2 0 0 0 1 heavy metal binding 5504 4 0 0 0 1 fatty acid binding 5501 6 0 0 0 1 retinoid binding 9882 2 0 0 0 1 blue light photoreceptor activity 9881 10 0 0 0 1 photoreceptor activity 5499 1 0 0 0 1 vitamin D binding 5498 3 0 0 0 1 sterol carrier activity 5496 25 0 0 6 0.4336 steroid binding 5489 121 0 0 32 0.0224 electron transporter activity 5488 3520 0 0 620 0.3851 binding 5487 6 0 0 1 1 nucleocytoplasmic transporter activity 5486 3 0 0 0 1 t-SNARE activity 5485 2 0 0 0 1 v-SNARE activity 5484 7 0 0 0 1 SNAP receptor activity 5483 1 0 0 0 1 soluble NSF attachment protein activity 5478 16 0 0 1 0.3337 intracellular transporter activity 5459 1 0 0 1 0.18 UDP-galactose transporter activity 5452 7 0 0 0 1 inorganic anion exchanger activity 5451 3 0 0 0 1 monovalent cation:proton antiporter activity 5432 3 0 0 0 1 calcium:sodium antiporter activity 5427 3 0 0 0 1 proton-dependent oligopeptide transporter activity 5415 2 0 0 0 1 nucleoside:sodium symporter activity 5412 1 0 0 0 1 glucose:sodium symporter activity 5403 1 0 0 0 1 hydrogen:sugar symporter-transporter activity 5402 1 0 0 0 1 cation:sugar symporter activity 16997 1 0 0 0 1 alpha-sialidase activity 16992 1 0 0 0 1 lipoate synthase activity 16986 2 0 0 0 1 transcription initiation factor activity 16979 3 0 0 1 0.4488 lipoate-protein ligase activity 16978 2 0 0 1 0.3277 lipoate-protein ligase B activity 16975 1 0 0 0 1 alpha-2 macroglobulin 16972 1 0 0 0 1 thiol oxidase activity 16971 1 0 0 0 1 flavin-linked sulfhydryl oxidase activity 16962 4 0 0 3 0.0202 receptor-associated protein activity 4999 4 0 0 0 1 vasoactive intestinal polypeptide receptor activity 4998 1 0 0 1 0.18 transferrin receptor activity 4997 1 0 0 0 1 thyrotropin-releasing hormone receptor activity 4996 1 0 0 0 1 thyroid-stimulating hormone receptor activity 4995 3 0 0 0 1 tachykinin receptor activity 4994 5 0 0 0 1 somatostatin receptor activity 4993 13 0 0 0 1 serotonin receptor activity 4992 1 0 0 0 1 platelet activating factor receptor activity 4991 1 0 0 0 1 parathyroid hormone receptor activity 4990 1 0 0 1 0.18 oxytocin receptor activity 4988 1 0 0 0 1 mu-opioid receptor activity 4987 1 0 0 0 1 kappa-opioid receptor activity 4986 1 0 0 0 1 delta-opioid receptor activity 4985 3 0 0 0 1 opioid receptor activity 4983 30 0 0 0 1 neuropeptide Y receptor activity 4982 1 0 0 0 1 N-formyl peptide receptor activity 4981 1 0 0 0 1 muscarinic acetylcholine receptor activity 4980 1 0 0 0 1 melanocyte stimulating hormone receptor activity 16944 4 0 0 0 1 Pol II transcription elongation factor activity 4978 1 0 0 0 1 adrenocorticotropin receptor activity 4977 5 0 0 0 1 melanocortin receptor activity 4974 3 0 0 0 1 leukotriene receptor activity 4971 4 0 0 0 1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 4970 15 0 0 0 1 inotropic glutamate receptor activity 16937 1 0 0 0 1 short branched-chain acyl-CoA dehydrogenase activity 16934 1 0 0 0 1 glycine-gated chloride channel activity 16933 1 0 0 0 1 glycine-gated ion channel activity 4969 4 0 0 0 1 histamine receptor activity 4968 1 0 0 0 1 gonadotropin-releasing hormone receptor activity 4967 3 0 0 0 1 glucagon receptor activity 4966 3 0 0 0 1 galanin receptor activity 4964 1 0 0 0 1 lutropin-choriogonadotropic hormone receptor activity 4963 1 0 0 0 1 follicle stimulating hormone receptor activity 4962 2 0 0 0 1 endothelin receptor activity 4960 1 0 0 0 1 thromboxane receptor activity 16923 1 0 0 1 0.18 ligand-dependent thyroid hormone receptor interactor activity 4959 1 0 0 0 1 prostaglandin I receptor activity 4958 1 0 0 0 1 prostaglandin F receptor activity 4957 4 0 0 0 1 prostaglandin E receptor activity 4956 1 0 0 0 1 prostaglandin D receptor activity 4955 7 0 0 0 1 prostaglandin receptor activity 4954 8 0 0 0 1 prostanoid receptor activity 4953 8 0 0 0 1 eicosanoid receptor activity 4952 3 0 0 0 1 dopamine receptor activity 4951 2 0 0 0 1 cholecystokinin receptor activity 4950 18 0 0 0 1 chemokine receptor activity 16917 29 0 0 0 1 GABA receptor activity 16916 1 0 0 0 1 inhibin 4949 2 0 0 0 1 cannabinoid receptor activity 4948 1 0 0 0 1 calcitonin receptor activity 4947 1 0 0 0 1 bradykinin receptor activity 4946 4 0 0 0 1 bombesin receptor activity 4945 3 0 0 0 1 angiotensin type II receptor activity 4944 1 0 0 0 1 C5a anaphylatoxin receptor activity 4943 1 0 0 0 1 C3a anaphylatoxin receptor activity 4942 4 0 0 0 1 anaphylatoxin receptor activity 4941 1 0 0 0 1 beta2-adrenergic receptor activity 4940 1 0 0 0 1 beta1-adrenergic receptor activity 16909 1 0 0 0 1 SAP kinase activity 16903 25 0 0 8 0.1109 "oxidoreductase activity, acting on the aldehyde or oxo group of donors" 16902 1 0 0 0 1 "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" 4939 3 0 0 0 1 beta-adrenergic receptor activity 4938 3 0 0 0 1 alpha2-adrenergic receptor activity 4937 3 0 0 0 1 alpha1-adrenergic receptor activity 4936 6 0 0 0 1 alpha-adrenergic receptor activity 4935 17 0 0 0 1 adrenoceptor activity 4931 5 0 0 0 1 ATP-gated cation channel activity 4930 240 0 0 4 0 G-protein coupled receptor activity 4928 10 0 0 0 1 frizzled receptor activity 4926 13 0 0 0 1 non-G-protein coupled 7TM receptor activity 4924 1 0 0 0 1 oncostatin-M receptor activity 4920 1 0 0 0 1 interleukin-10 receptor activity 4918 1 0 0 0 1 interleukin-8 receptor activity 4910 1 0 0 0 1 "interleukin-1, Type II, blocking receptor activity" 4909 10 0 0 0 1 "interleukin-1, Type I, activating receptor activity" 4908 11 0 0 0 1 interleukin-1 receptor activity 4907 31 0 0 1 0.0319 interleukin receptor activity 4905 1 0 0 0 1 interferon-alpha/beta receptor activity 4904 1 0 0 0 1 interferon receptor activity 5391 9 0 0 3 0.2105 sodium/potassium-exchanging ATPase activity 5388 4 0 0 1 0.5481 calcium-transporting ATPase activity 5386 270 0 0 63 0.0234 carrier activity 5385 2 0 0 0 1 zinc ion transporter activity 5381 1 0 0 0 1 iron ion transporter activity 5375 3 0 0 1 0.4488 copper ion transporter activity 5372 1 0 0 0 1 water transporter activity 5369 1 0 0 0 1 taurine:sodium symporter activity 5368 1 0 0 0 1 taurine transporter activity 5360 1 0 0 0 1 insulin-responsive hydrogen:glucose transporter activity 5355 8 0 0 1 1 glucose transporter activity 5354 1 0 0 0 1 galactose transporter activity 5353 2 0 0 0 1 fructose transporter activity 5351 14 0 0 3 0.7274 sugar porter activity 5350 1 0 0 0 1 pyrimidine transporter activity 5345 1 0 0 0 1 purine transporter activity 5344 3 0 0 2 0.0855 oxygen transporter activity 5343 3 0 0 0 1 organic acid:sodium symporter activity 5342 43 0 0 3 0.0707 organic acid transporter activity 5338 2 0 0 1 0.3277 nucleotide-sugar transporter activity 5337 3 0 0 0 1 nucleoside transporter activity 5335 1 0 0 0 1 serotonin:sodium symporter activity 5330 1 0 0 0 1 dopamine:sodium symporter activity 5329 1 0 0 0 1 dopamine transporter activity 5328 8 0 0 1 1 neurotransmitter:sodium symporter activity 5326 9 0 0 1 1 neurotransmitter transporter activity 5319 24 0 0 3 0.6035 lipid transporter activity 5315 5 0 0 1 1 inorganic phosphate transporter activity 5313 1 0 0 0 1 glutamate transporter activity 5311 6 0 0 0 1 sodium:dicarboxylate/tricarboxylate symporter activity 5310 8 0 0 0 1 dicarboxylic acid transporter activity 5309 1 0 0 0 1 creatine:sodium symporter activity 5308 1 0 0 0 1 creatine transporter activity 16899 3 0 0 0 1 "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor" 16896 7 0 0 0 1 "exoribonuclease activity, producing 5'-phosphomonoesters" 16892 5 0 0 0 1 "endoribonuclease activity, producing other than 5'-phosphomonoesters" 16891 7 0 0 1 1 "endoribonuclease activity, producing 5'-phosphomonoesters" 16889 1 0 0 0 1 "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" 16888 2 0 0 0 1 "endodeoxyribonuclease activity, producing 5'-phosphomonoesters" 16887 174 0 0 47 0.0026 ATPase activity 16886 30 0 0 6 0.811 "ligase activity, forming phosphoric ester bonds" 16885 4 0 0 1 0.5481 "ligase activity, forming carbon-carbon bonds" 16884 6 0 0 0 1 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor" 16883 12 0 0 1 0.7058 other carbon-nitrogen ligase activity 16882 1 0 0 0 1 cyclo-ligase activity 16881 34 0 0 13 0.0054 acid-D-amino acid ligase activity 16880 3 0 0 1 0.4488 acid-ammonia (or amide) ligase activity 16879 58 0 0 16 0.0834 "ligase activity, forming carbon-nitrogen bonds" 16878 3 0 0 1 0.4488 acid-thiol ligase activity 16877 6 0 0 1 1 "ligase activity, forming carbon-sulfur bonds" 16876 27 0 0 6 0.6137 "ligase activity, forming aminoacyl-tRNA and related compounds" 16875 27 0 0 6 0.6137 "ligase activity, forming carbon-oxygen bonds" 16874 115 0 0 27 0.1406 ligase activity 16873 9 0 0 2 0.6688 other isomerase activity 16870 1 0 0 0 1 "intramolecular transferase activity, transferring other groups" 16868 9 0 0 3 0.2105 "intramolecular transferase activity, phosphotransferases" 16866 10 0 0 3 0.4 intramolecular transferase activity 16865 5 0 0 2 0.2224 "intramolecular isomerase activity, other intramolecular oxidoreductases" 16864 3 0 0 2 0.0855 "intramolecular isomerase activity, transposing S-S bonds" 16863 6 0 0 0 1 "intramolecular isomerase activity, transposing C=C bonds" 16861 6 0 0 2 0.2957 "intramolecular isomerase activity, interconverting aldoses and ketoses" 16860 20 0 0 6 0.1542 intramolecular isomerase activity 4896 49 0 0 1 0.0012 hematopoietin/interferon-class (D200-domain) cytokine receptor activity 4895 27 0 0 4 0.8058 cell adhesion receptor activity 4891 1 0 0 0 1 glycine-inhibited chloride channel activity 4890 29 0 0 0 1 GABA-A receptor activity 16859 25 0 0 9 0.032 cis-trans isomerase activity 16858 1 0 0 0 1 "racemase and epimerase activity, acting on other compounds" 16857 2 0 0 0 1 "racemase and epimerase activity, acting on carbohydrates and derivatives" 16856 1 0 0 0 1 "racemase and epimerase activity, acting on hydroxy acids and derivatives" 16855 1 0 0 0 1 "racemase and epimerase activity, acting on amino acids and derivatives" 16854 5 0 0 0 1 racemase and epimerase activity 16853 77 0 0 22 0.0238 isomerase activity 16850 1 0 0 0 1 other lyase activity 4889 13 0 0 0 1 nicotinic acetylcholine-activated cation-selective channel activity 4888 476 0 0 23 0 transmembrane receptor activity 4887 3 0 0 0 1 thyroid hormone receptor activity 4883 1 0 0 1 0.18 glucocorticoid receptor activity 4882 1 0 0 0 1 androgen receptor activity 16849 13 0 0 0 1 phosphorus-oxygen lyase activity 16846 5 0 0 1 1 carbon-sulfur lyase activity 16842 3 0 0 2 0.0855 amidine-lyase activity 16841 4 0 0 0 1 ammonia-lyase activity 16840 7 0 0 2 0.6168 carbon-nitrogen lyase activity 4879 46 0 0 3 0.0513 ligand-dependent nuclear receptor activity 4878 1 0 0 0 1 complement component C5 receptor activity 4875 1 0 0 0 1 complement receptor activity 4872 733 0 0 59 0 receptor activity 4871 1135 0 0 91 0 signal transducer activity 16839 3 0 0 1 0.4488 other carbon-oxygen lyase activity 16838 1 0 0 1 0.0103 "carbon-oxygen lyase activity, acting on phosphates" 16836 21 0 0 3 1 hydro-lyase activity 16835 25 0 0 5 0.794 carbon-oxygen lyase activity 16834 1 0 0 0 1 other carbon-carbon lyase activity 16833 6 0 0 1 1 oxo-acid-lyase activity 16832 4 0 0 2 0.1509 aldehyde-lyase activity 16831 17 0 0 1 0.3391 carboxy-lyase activity 16830 28 0 0 5 1 carbon-carbon lyase activity 4869 11 0 0 3 0.429 cysteine protease inhibitor activity 4868 1 0 0 0 1 serpin 4867 44 0 0 11 0.2365 serine protease inhibitor activity 4866 61 0 0 16 0.0955 endopeptidase inhibitor activity 4864 3 0 0 1 0.4488 protein phosphatase inhibitor activity 4862 2 0 0 1 0.3277 cAMP-dependent protein kinase inhibitor activity 4861 8 0 0 0 1 cyclin-dependent protein kinase inhibitor activity 4860 13 0 0 1 0.4854 protein kinase inhibitor activity 16829 86 0 0 13 0.5726 lyase activity 16824 3 0 0 0 1 "hydrolase activity, acting on acid halide bonds" 16823 2 0 0 0 1 "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances" 16822 2 0 0 0 1 "hydrolase activity, acting on acid carbon-carbon bonds" 16821 5 0 0 0 1 "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" 16820 102 0 0 33 0.0004 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" 4859 3 0 0 3 0.0058 phospholipase inhibitor activity 4857 92 0 0 23 0.0994 enzyme inhibitor activity 4855 1 0 0 0 1 xanthine oxidase activity 4854 1 0 0 0 1 xanthine dehydrogenase activity 4853 1 0 0 0 1 uroporphyrinogen decarboxylase activity 4852 1 0 0 0 1 uroporphyrinogen-III synthase activity 16818 296 0 0 76 0.0008 "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" 16817 301 0 0 76 0.0012 "hydrolase activity, acting on acid anhydrides" 16815 2 0 0 2 0.0324 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles" 16814 14 0 0 2 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines" 16813 9 0 0 1 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines" 16812 1 0 0 0 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides" 16811 9 0 0 2 0.6688 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" 16810 38 0 0 7 1 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" 4849 1 0 0 0 1 uridine kinase activity 4844 1 0 0 0 1 uracil DNA N-glycosylase activity 4843 4 0 0 1 0.5481 ubiquitin-specific protease activity 4842 29 0 0 10 0.0284 ubiquitin-protein ligase activity 4840 19 0 0 9 0.0031 ubiquitin conjugating enzyme activity 16808 2 0 0 0 1 proprotein convertase activity 16806 5 0 0 2 0.2224 dipeptidyl-peptidase and tripeptidyl-peptidase activity 16805 6 0 0 0 1 dipeptidase activity 16803 3 0 0 2 0.0855 ether hydrolase activity 16802 2 0 0 2 0.0324 thioether hydrolase activity 16801 5 0 0 4 0.0045 "hydrolase activity, acting on ether bonds" 4838 1 0 0 0 1 tyrosine aminotransferase activity 4833 1 0 0 0 1 "tryptophan 2,3 dioxygenase activity" 4832 1 0 0 0 1 valine-tRNA ligase activity 4831 1 0 0 1 0.18 tyrosine-tRNA ligase activity 4830 2 0 0 1 0.3277 tryptophan-tRNA ligase activity 4829 1 0 0 0 1 threonine-tRNA ligase activity 4828 1 0 0 0 1 serine-tRNA ligase activity 4826 1 0 0 0 1 phenylalanine-tRNA ligase activity 4824 1 0 0 1 0.18 lysine-tRNA ligase activity 4821 2 0 0 0 1 histidine-tRNA ligase activity 4820 1 0 0 0 1 glycine-tRNA ligase activity 20037 3 0 0 1 0.4488 heme binding 4817 1 0 0 1 0.18 cysteine-tRNA ligase activity 4816 1 0 0 1 0.18 asparagine-tRNA ligase activity 4815 2 0 0 1 0.3277 aspartate-tRNA ligase activity 4814 2 0 0 0 1 arginine-tRNA ligase activity 4812 27 0 0 6 0.6137 tRNA ligase activity 4807 1 0 0 1 0.18 triose-phosphate isomerase activity 4806 5 0 0 0 1 triacylglycerol lipase activity 4802 3 0 0 3 0.0058 transketolase activity 4801 2 0 0 2 0.0324 transaldolase activity 4800 3 0 0 0 1 thyroxine deiodinase activity 5290 2 0 0 0 1 histidine transporter activity 5286 1 0 0 0 1 basic amino acid permease activity 5283 1 0 0 0 1 sodium:amino acid transporter activity 5279 24 0 0 3 0.6035 amino acid-polyamine transporter activity 5276 2 0 0 0 1 hydrogen:vesicular amine antiporter activity 5275 36 0 0 3 0.1886 amine/polyamine transporter activity 5272 12 0 0 2 1 sodium channel activity 5267 68 0 0 0 1 potassium channel activity 5262 41 0 0 0 1 calcium channel activity 5261 151 0 0 2 0 cation channel activity 5254 20 0 0 5 0.3863 chloride channel activity 5253 25 0 0 6 0.4336 anion channel activity 5251 1 0 0 0 1 delayed rectifier potassium channel activity 5249 39 0 0 0 1 voltage-gated potassium channel activity 5248 8 0 0 0 1 voltage-gated sodium channel activity 5247 11 0 0 1 0.701 voltage-gated chloride channel activity 5246 3 0 0 0 1 calcium channel regulator activity 5245 19 0 0 0 1 voltage-gated calcium channel activity 5244 90 0 0 1 0 voltage-gated ion channel activity 5243 11 0 0 0 1 gap-junction forming channel activity 5242 15 0 0 0 1 inward rectifier potassium channel activity 5237 1 0 0 0 1 inhibitory extracellular ligand-gated ion channel activity 5234 15 0 0 0 1 glutamate-gated ion channel activity 5232 2 0 0 0 1 serotonin-activated cation-selective channel activity 5231 36 0 0 0 1 excitatory extracellular ligand-gated ion channel activity 5230 58 0 0 0 1 extracellular ligand-gated ion channel activity 5229 2 0 0 1 0.3277 intracellular calcium activated chloride channel activity 5224 4 0 0 3 0.0202 ATP-binding and phosphorylation-dependent chloride channel activity 5223 1 0 0 0 1 intracellular cGMP activated cation channel activity 5221 2 0 0 0 1 intracellular cyclic nucleotide activated cation channel activity 5220 1 0 0 0 1 "inositol 1,4,5-triphosphate-sensitive calcium-release channel activity" 5217 9 0 0 4 0.0615 intracellular ligand-gated ion channel activity 5216 221 0 0 10 0 ion channel activity 5215 869 0 0 138 0.0879 transporter activity 5214 3 0 0 0 1 structural constituent of cuticle (sensu Insecta) activity 5212 17 0 0 1 0.3391 structural constituent of eye lens 5201 53 0 0 6 0.2797 extracellular matrix structural constituent 5200 57 0 0 15 0.1172 structural constituent of cytoskeleton 16799 9 0 0 0 1 "hydrolase activity, hydrolyzing N-glycosyl compounds" 16798 50 0 0 6 0.355 "hydrolase activity, acting on glycosyl bonds" 16791 125 0 0 16 0.1573 phosphoric monoester hydrolase activity 16790 24 0 0 5 0.7889 thiolester hydrolase activity 16789 54 0 0 11 0.5969 carboxylic ester hydrolase activity 16788 289 0 0 36 0.012 "hydrolase activity, acting on ester bonds" 16787 1008 0 0 191 0.3975 hydrolase activity 16784 2 0 0 0 1 3-mercaptopyruvate sulfurtransferase activity 16783 3 0 0 0 1 sulfurtransferase activity 16782 25 0 0 1 0.0701 "transferase activity, transferring sulfur-containing groups" 16781 1 0 0 0 1 "phosphotransferase activity, paired acceptors" 16780 6 0 0 1 1 "phosphotransferase activity, for other substituted phosphate groups" 16779 44 0 0 10 0.4298 nucleotidyltransferase activity 16778 4 0 0 1 0.5481 diphosphotransferase activity 16776 19 0 0 6 0.1337 "phosphotransferase activity, phosphate group as acceptor" 16775 8 0 0 2 0.641 "phosphotransferase activity, nitrogenous group as acceptor" 16774 4 0 0 2 0.1509 "phosphotransferase activity, carboxyl group as acceptor" 16773 423 0 0 53 0.0021 "phosphotransferase activity, alcohol group as acceptor" 16772 501 0 0 72 0.0292 "transferase activity, transferring phosphorus-containing groups" 16769 21 0 0 3 1 "transferase activity, transferring nitrogenous groups" 16768 1 0 0 0 1 spermine synthase activity 16765 28 0 0 9 0.0785 "transferase activity, transferring alkyl or aryl (other than methyl) groups" 16764 11 0 0 1 0.701 "transferase activity, transferring other glycosyl groups" 16763 10 0 0 1 1 "transferase activity, transferring pentosyl groups" 4799 1 0 0 0 1 thymidylate synthase activity 4798 1 0 0 0 1 thymidylate kinase activity 4797 2 0 0 0 1 thymidine kinase activity 4796 1 0 0 0 1 thromboxane-A synthase activity 4794 1 0 0 0 1 threonine dehydratase activity 4792 2 0 0 0 1 thiosulfate sulfurtransferase activity 4791 2 0 0 3 0.0201 thioredoxin reductase (NADPH) activity 16758 59 0 0 13 0.397 "transferase activity, transferring hexosyl groups" 16757 98 0 0 18 0.8949 "transferase activity, transferring glycosyl groups" 16756 1 0 0 1 0.0103 glutathione gamma-glutamylcysteinyltransferase activity 16755 10 0 0 2 0.6983 "transferase activity, transferring amino-acyl groups" 4788 1 0 0 0 1 thiamin pyrophosphokinase activity 4785 4 0 0 2 0.1509 "copper, zinc superoxide dismutase activity" 4784 5 0 0 2 0.2224 superoxide dismutase activity 4782 1 0 0 0 1 sulfinoalanine decarboxylase activity 4781 2 0 0 1 0.3277 sulfate adenylyltransferase (ATP) activity 16747 59 0 0 14 0.2367 "transferase activity, transferring groups other than amino-acyl groups" 16746 66 0 0 15 0.3329 "transferase activity, transferring acyl groups" 16745 5 0 0 5 0.0002 transketolase and transaldolase activity 16744 5 0 0 5 0.0002 "transferase activity, transferring aldehyde or ketonic groups" 16743 1 0 0 0 1 carboxyl- and carbamoyltransferase activity 16742 4 0 0 2 0.1509 "hydroxymethyl-, formyl- and related transferase activity" 16741 56 0 0 7 0.3813 "transferase activity, transferring one-carbon groups" 16740 824 0 0 131 0.0992 transferase activity 4779 2 0 0 1 0.3277 sulfate adenylyltransferase activity 4777 1 0 0 0 1 succinate-semialdehyde dehydrogenase activity 4774 1 0 0 0 1 succinate-CoA ligase activity 4773 1 0 0 0 1 steryl-sulfatase activity 4772 1 0 0 0 1 sterol O-acyltransferase activity 4770 1 0 0 0 1 sterol carrier protein X-related thiolase activity 16731 1 0 0 0 1 "oxidoreductase activity, acting on reduced ferredoxin as donor, NAD or NADP as acceptor" 16730 1 0 0 0 1 "oxidoreductase activity, acting on iron-sulfur proteins as donors" 4769 2 0 0 0 1 steroid delta-isomerase activity 4768 2 0 0 1 0.3277 stearoyl-CoA desaturase activity 4767 2 0 0 0 1 sphingomyelin phosphodiesterase activity 4766 1 0 0 0 1 spermidine synthase activity 16728 2 0 0 1 0.3277 "oxidoreductase activity, acting on CH2 groups, disulfide as acceptor" 16725 2 0 0 1 0.3277 "oxidoreductase activity, acting on CH2 groups" 16724 1 0 0 1 0.18 "oxidoreductase activity, oxidizing metal ions, oxygen as acceptor" 16722 1 0 0 1 0.18 "oxidoreductase activity, oxidizing metal ions" 16721 5 0 0 2 0.2224 "oxidoreductase activity, acting on superoxide radicals as acceptor" 4759 7 0 0 0 1 serine esterase activity 4758 2 0 0 0 1 serine C-palmitoyltransferase activity 4757 1 0 0 0 1 sepiapterin reductase activity 4756 1 0 0 0 1 "selenide, water dikinase activity" 4751 1 0 0 0 1 ribose-5-phosphate isomerase activity 4750 1 0 0 0 1 ribulose-phosphate 3-epimerase activity 16718 9 0 0 2 0.6688 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" 16716 1 0 0 0 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen" 16715 2 0 0 0 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen" 16714 2 0 0 0 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen" 4749 3 0 0 1 0.4488 ribose-phosphate pyrophosphokinase activity 4748 2 0 0 1 0.3277 ribonucleoside-diphosphate reductase activity 4745 1 0 0 0 1 retinol dehydrogenase activity 4743 2 0 0 1 0.3277 pyruvate kinase activity 4742 1 0 0 0 1 dihydrolipoamide S-acetyltransferase activity 16709 10 0 0 1 1 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen" 16706 7 0 0 3 0.1154 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" 16705 32 0 0 6 0.8205 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" 16702 24 0 0 3 0.6035 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" 16701 24 0 0 3 0.6035 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen" 4739 3 0 0 1 0.4488 pyruvate dehydrogenase (lipoamide) activity 4738 3 0 0 1 0.4488 pyruvate dehydrogenase activity 4736 1 0 0 0 1 pyruvate carboxylase activity 4735 1 0 0 0 1 pyrroline 5-carboxylate reductase activity 4731 1 0 0 0 1 purine-nucleoside phosphorylase activity 4730 2 0 0 0 1 pseudouridylate synthase activity 4729 1 0 0 1 0.18 protoporphyrinogen oxidase activity 4727 6 0 0 2 0.2957 prenylated protein tyrosine phosphatase activity 4726 6 0 0 0 1 non-membrane spanning protein tyrosine phosphatase activity 4725 43 0 0 5 0.3252 protein tyrosine phosphatase activity 4724 1 0 0 0 1 magnesium-dependent protein serine/threonine phosphatase activity 4723 1 0 0 1 0.18 calcium-dependent protein serine/threonine phosphatase activity 4722 27 0 0 7 0.3118 protein serine/threonine phosphatase activity 4721 85 0 0 12 0.3963 protein phosphatase activity 4720 2 0 0 0 1 protein-lysine 6-oxidase activity 4719 1 0 0 0 1 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 4718 2 0 0 0 1 Janus kinase activity 4716 4 0 0 0 1 receptor signaling protein tyrosine kinase activity 4715 3 0 0 1 0.4488 non-membrane spanning protein tyrosine kinase activity 4714 42 0 0 4 0.2236 transmembrane receptor protein tyrosine kinase activity 4713 248 0 0 24 0.0003 protein tyrosine kinase activity 4712 4 0 0 1 0.5481 protein threonine/tyrosine kinase activity 4709 7 0 0 0 1 MAP kinase kinase kinase activity 4708 2 0 0 1 0.3277 MAP kinase kinase activity 4707 12 0 0 1 0.7058 MAP kinase activity 4705 1 0 0 0 1 JUN kinase activity 4703 6 0 0 1 1 G-protein coupled receptor kinase activity 4702 35 0 0 3 0.1861 receptor signaling protein serine/threonine kinase activity 339 1 0 0 0 1 RNA cap binding 17174 1 0 0 0 1 glycine N-methyltransferase activity 17172 1 0 0 0 1 cysteine dioxygenase activity 17169 4 0 0 0 1 CDP-alcohol phosphatidyltransferase activity 17166 1 0 0 1 0.18 vinculin binding 17160 1 0 0 0 1 Ral interactor activity 5198 366 0 0 124 0 structural molecule activity 5194 66 0 0 9 0.4226 cell adhesion molecule activity 17155 1 0 0 0 1 sodium:hydrogen antiporter regulator activity 17153 1 0 0 0 1 sodium:dicarboxylate symporter activity 5185 2 0 0 0 1 neurohypophyseal hormone activity 5184 13 0 0 1 0.4854 neuropeptide hormone activity 5181 6 0 0 0 1 glycopeptide hormone 5180 14 0 0 0 1 peptide hormone 17149 1 0 0 0 1 protein biosynthesis inhibitor activity 17140 1 0 0 0 1 lipoic acid synthase activity 5179 68 0 0 1 0 hormone activity 5178 5 0 0 2 0.2224 integrin binding 5176 1 0 0 0 1 Neu/ErbB-2 receptor binding 5172 2 0 0 0 1 vascular endothelial growth factor receptor binding 5171 1 0 0 0 1 hepatocyte growth factor receptor binding 17137 2 0 0 0 1 Rab interactor activity 17136 1 0 0 0 1 NAD-dependent histone deacetylase activity 17134 1 0 0 1 0.18 fibroblast growth factor binding 17132 1 0 0 0 1 cyclic nucleotide dependent guanyl-nucleotide exchange factor activity 5166 1 0 0 0 1 neurotrophin p75 receptor binding 5165 1 0 0 0 1 neurotrophin receptor binding 5164 15 0 0 2 1 tumor necrosis factor receptor binding 5161 1 0 0 0 1 platelet-derived growth factor receptor binding 5160 5 0 0 0 1 transforming growth factor-beta receptor binding 17127 2 0 0 0 1 cholesterol transporter activity 17125 2 0 0 0 1 deoxycytidyl transferase activity 17124 4 0 0 1 0.5481 SH3-domain binding 17120 1 0 0 0 1 polyphosphoinositide phosphatase activity 5158 5 0 0 0 1 insulin receptor binding 5153 1 0 0 1 0.18 interleukin-8 receptor binding 17114 1 0 0 0 1 wide-spectrum protease inhibitor activity 17113 1 0 0 0 1 dihydropyrimidine dehydrogenase activity 17112 1 0 0 0 1 Rab guanyl-nucleotide exchange factor activity 17110 1 0 0 0 1 nucleoside diphosphatase activity 5149 6 0 0 0 1 interleukin-1 receptor binding 5147 1 0 0 0 1 oncostatin-M receptor binding 5146 1 0 0 0 1 leukemia inhibitory factor receptor binding 5144 1 0 0 0 1 interleukin-13 receptor binding 5143 1 0 0 0 1 interleukin-12 receptor binding 5140 1 0 0 0 1 interleukin-9 receptor binding 17108 1 0 0 0 1 flap endonuclease activity 5139 1 0 0 0 1 interleukin-7 receptor binding 5138 1 0 0 0 1 interleukin-6 receptor binding 5137 1 0 0 0 1 interleukin-5 receptor binding 5136 1 0 0 0 1 interleukin-4 receptor binding 5135 1 0 0 0 1 interleukin-3 receptor binding 5134 1 0 0 0 1 interleukin-2 receptor binding 5133 1 0 0 0 1 interferon-gamma receptor binding 5131 1 0 0 0 1 growth hormone receptor binding 5129 1 0 0 0 1 granulocyte macrophage colony-stimulating factor receptor binding 5128 2 0 0 0 1 erythropoietin receptor binding 5126 25 0 0 0 1 hematopoietin/interferon-class (D200-domain) cytokine receptor binding 5125 138 0 0 11 0.0011 cytokine activity 5112 1 0 0 0 1 Notch binding 5106 4 0 0 0 1 ephrin 5104 15 0 0 0 1 fibroblast growth factor receptor binding 5102 265 0 0 16 0 receptor binding 5100 1 0 0 0 1 Rho GTPase activator activity 16684 23 0 0 11 0.001 "oxidoreductase activity, acting on peroxide as acceptor" 16676 12 0 0 9 0 "oxidoreductase activity, acting on heme group of donors, oxygen as acceptor" 16675 12 0 0 9 0 "oxidoreductase activity, acting on heme group of donors" 16671 2 0 0 0 1 "oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor" 16670 1 0 0 0 1 "oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor" 16668 2 0 0 1 0.3277 "oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor" 16667 5 0 0 1 1 "oxidoreductase activity, acting on sulfur group of donors" 16666 1 0 0 0 1 nitrite reductase activity 16665 1 0 0 0 1 "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" 16661 1 0 0 0 1 "oxidoreductase activity, acting on other nitrogenous compounds as donors" 4699 1 0 0 0 1 calcium independent protein kinase C activity 4698 1 0 0 0 1 calcium dependent protein kinase C activity 4697 2 0 0 0 1 protein kinase C activity 4696 1 0 0 0 1 glycogen synthase kinase 3 activity 4693 40 0 0 6 0.8361 cyclin-dependent protein kinase activity 4692 2 0 0 0 1 cGMP-dependent protein kinase activity 4691 9 0 0 2 0.6688 cAMP-dependent protein kinase activity 4690 9 0 0 2 0.6688 cyclic-nucleotide dependent protein kinase activity 16659 14 0 0 8 0.0012 "oxidoreductase activity, acting on NADH or NADPH, other acceptor" 16657 2 0 0 0 1 "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" 16655 13 0 0 7 0.0038 "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" 16654 3 0 0 3 0.0058 "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" 16652 3 0 0 2 0.0855 "oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor" 16651 27 0 0 16 0 "oxidoreductase activity, acting on NADH or NADPH" 16650 1 0 0 0 1 "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" 4689 4 0 0 1 0.5481 phosphorylase kinase activity 4685 6 0 0 0 1 calcium/calmodulin-dependent protein kinase activity 4684 2 0 0 0 1 calmodulin-dependent protein kinase I activity 4683 10 0 0 1 1 calmodulin regulated protein kinase activity 4682 3 0 0 1 0.4488 protein kinase CK2 activity 4681 1 0 0 1 0.18 casein kinase I activity 4680 4 0 0 2 0.1509 casein kinase activity 16649 1 0 0 0 1 "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor" 16647 1 0 0 0 1 "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor" 16646 5 0 0 0 1 "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor" 16645 8 0 0 0 1 "oxidoreductase activity, acting on the CH-NH group of donors" 16642 1 0 0 0 1 "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor" 16641 6 0 0 0 1 "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor" 4679 7 0 0 0 1 SNF1A/AMP-activated protein kinase activity 4676 1 0 0 0 1 3-phosphoinositide-dependent protein kinase activity 4675 12 0 0 2 1 transmembrane receptor protein serine/threonine kinase activity 4674 342 0 0 38 0.0004 protein serine/threonine kinase activity 4673 4 0 0 0 1 protein histidine kinase activity 4672 376 0 0 45 0.0014 protein kinase activity 4671 1 0 0 0 1 protein-S-isoprenylcysteine O-methyltransferase activity 16639 1 0 0 0 1 "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor" 16638 8 0 0 0 1 "oxidoreductase activity, acting on the CH-NH2 group of donors" 16637 12 0 0 2 1 "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" 16635 1 0 0 1 0.18 "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor" 16634 6 0 0 1 1 "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor" 4668 4 0 0 0 1 protein-arginine deiminase activity 4667 3 0 0 2 0.0855 prostaglandin-D synthase activity 4666 2 0 0 0 1 prostaglandin-endoperoxide synthase activity 16628 5 0 0 2 0.2224 "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" 16627 23 0 0 6 0.2846 "oxidoreductase activity, acting on the CH-CH group of donors" 16624 6 0 0 1 1 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor" 16623 1 0 0 0 1 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor" 16621 2 0 0 0 1 cinnamoyl-CoA reductase activity 16620 18 0 0 7 0.0304 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" 4659 13 0 0 5 0.0679 prenyltransferase activity 4658 2 0 0 0 1 propionyl-CoA carboxylase activity 4657 1 0 0 0 1 proline dehydrogenase activity 4656 3 0 0 2 0.0855 "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" 4655 1 0 0 0 1 porphobilinogen synthase activity 4653 5 0 0 4 0.0045 polypeptide N-acetylgalactosaminyltransferase activity 4652 3 0 0 1 0.4488 polynucleotide adenylyltransferase activity 16619 1 0 0 0 1 malate dehydrogenase (oxaloacetate decarboxylating) activity 16616 47 0 0 20 0.0001 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" 16615 4 0 0 3 0.0202 malate dehydrogenase activity 16614 51 0 0 21 0.0001 "oxidoreductase activity, acting on CH-OH group of donors" 4649 1 0 0 0 1 poly(ADP-ribose) glycohydrolase activity 4645 5 0 0 0 1 phosphorylase activity 4644 1 0 0 0 1 phosphoribosylglycinamide formyltransferase activity 4643 1 0 0 1 0.18 phosphoribosylaminoimidazole-carboxamide formyltransferase activity 4641 1 0 0 0 1 phosphoribosylformylglycinamidine cyclo-ligase activity 287 71 0 0 15 0.5335 magnesium ion binding 285 1 0 0 0 1 1-phosphatidylinositol-3-phosphate 5-kinase activity 4639 1 0 0 0 1 phosphoribosylaminoimidazole-succinocarboxamide synthase activity 4638 1 0 0 0 1 phosphoribosylaminoimidazole carboxylase activity 4637 2 0 0 0 1 phosphoribosylamine-glycine ligase activity 4634 3 0 0 1 0.4488 phosphopyruvate hydratase activity 4630 4 0 0 0 1 phospholipase D activity 4629 8 0 0 1 1 phospholipase C activity 4628 1 0 0 0 1 calcium-independent cytosolic phospholipase A2 activity 4626 1 0 0 0 1 cytosolic phospholipase A2 activity 4624 1 0 0 0 1 secreted phospholipase A2 activity 4623 13 0 0 3 0.715 phospholipase A2 activity 4622 3 0 0 1 0.4488 lysophospholipase activity 4621 1 0 0 0 1 glycoprotein phospholipase D activity 4620 27 0 0 6 0.6137 phospholipase activity 268 2 0 0 0 1 peroxisome targeting sequence binding 260 1 0 0 0 1 hydrogen-translocating V-type ATPase activity 4619 2 0 0 1 0.3277 phosphoglycerate mutase activity 4618 2 0 0 1 0.3277 phosphoglycerate kinase activity 4617 1 0 0 2 0.0855 phosphoglycerate dehydrogenase activity 4616 1 0 0 1 0.0103 phosphogluconate dehydrogenase (decarboxylating) activity 4615 2 0 0 0 1 phosphomannomutase activity 4614 2 0 0 1 0.3277 phosphoglucomutase activity 4613 1 0 0 0 1 phosphoenolpyruvate carboxykinase (GTP) activity 4612 1 0 0 0 1 phosphoenolpyruvate carboxykinase (ATP) activity 4611 2 0 0 0 1 phosphoenolpyruvate carboxykinase activity 4610 1 0 0 1 0.18 phosphoacetylglucosamine mutase activity 257 2 0 0 2 0.0324 nitrilase activity 254 1 0 0 1 0.18 C-4 methyl sterol oxidase activity 4608 1 0 0 0 1 phosphatidylethanolamine N-methyltransferase activity 4607 1 0 0 0 1 phosphatidylcholine-sterol O-acyltransferase activity 4605 2 0 0 1 0.3277 phosphatidate cytidylyltransferase activity 4604 1 0 0 0 1 phosphoadenylyl-sulfate reductase (thioredoxin) activity 4603 1 0 0 0 1 phenylethanolamine N-methyltransferase activity 4602 5 0 0 3 0.0437 glutathione peroxidase activity 4601 23 0 0 11 0.001 peroxidase activity 247 1 0 0 0 1 C-8 sterol isomerase activity 224 1 0 0 1 0.18 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity 215 1 0 0 1 0.18 tRNA 2'-phosphotransferase activity 211 2 0 0 1 0.3277 protein degradation tagging activity 9497 2 0 0 2 0.0324 3Fe-4S/4Fe-4S electron transfer carrier 9492 2 0 0 0 1 2Fe-2S electron transfer carrier 17080 1 0 0 0 1 sodium channel regulator activity 17076 997 0 0 198 0.098 purine nucleotide binding 17072 3 0 0 1 0.4488 tubulin-specific chaperone activity 17070 2 0 0 1 0.3277 U6 snRNA binding 17069 2 0 0 1 0.3277 snRNA binding 17068 1 0 0 0 1 glutamyl-tRNA(Gln) amidotransferase activity 9457 1 0 0 0 1 flavodoxin 17061 1 0 0 0 1 5'-methylthioadenosine phosphorylase activity 5099 3 0 0 0 1 Ras GTPase activator activity 5097 5 0 0 2 0.2224 Rab GTPase activator activity 5096 45 0 0 6 0.5587 GTPase activator activity 5095 5 0 0 0 1 GTPase inhibitor activity 5094 3 0 0 1 0.4488 Rho GDP-dissociation inhibitor activity 5093 2 0 0 2 0.0324 RAB GDP-dissociation inhibitor activity 5092 5 0 0 3 0.0437 GDP-dissociation inhibitor activity 5091 1 0 0 1 0.18 guanyl-nucleotide exchange factor adaptor activity 17057 1 0 0 1 0.18 6-phosphogluconolactonase activity 17050 1 0 0 0 1 D-erythro-sphingosine kinase activity 5089 5 0 0 0 1 Rho guanyl-nucleotide exchange factor activity 5086 2 0 0 1 0.3277 ARF guanyl-nucleotide exchange factor activity 5085 36 0 0 6 1 guanyl-nucleotide exchange factor activity 5083 70 0 0 11 0.7545 small GTPase regulatory/interacting protein activity 5080 2 0 0 1 0.3277 protein kinase C binding 17047 1 0 0 0 1 adrenocorticotropin-releasing hormone binding 17046 1 0 0 0 1 polypeptide hormone binding 17040 2 0 0 1 0.3277 ceramidase activity 5079 7 0 0 0 1 protein kinase A anchor protein activity 5078 1 0 0 0 1 MAP-kinase scaffold protein activity 5076 10 0 0 1 1 receptor signaling protein serine/threonine kinase signaling protein activity 5072 2 0 0 0 1 "TGFbeta receptor, cytoplasmic mediator activity" 5071 2 0 0 0 1 transmembrane receptor protein serine/threonine kinase signaling protein activity 5070 9 0 0 1 1 SH3/SH2 adaptor protein activity 17039 1 0 0 0 1 dipeptidyl-peptidase III activity 5069 10 0 0 1 1 transmembrane receptor protein tyrosine kinase docking protein activity 5066 13 0 0 1 0.4854 transmembrane receptor protein tyrosine kinase signaling protein activity 17028 1 0 0 0 1 protein stabilization activity 17022 2 0 0 0 1 myosin binding 5057 80 0 0 6 0.012 receptor signaling protein activity 5055 2 0 0 2 0.0324 laminin receptor activity 5053 1 0 0 0 1 peroxisome targeting signal-2 receptor activity 5051 2 0 0 0 1 peroxisome targeting signal receptor activity 17018 8 0 0 3 0.1608 myosin phosphatase activity 17016 1 0 0 0 1 Ras interactor activity 5048 9 0 0 2 0.6688 signal sequence binding 5046 2 0 0 0 1 KDEL sequence binding 5044 14 0 0 0 1 scavenger receptor activity 5042 1 0 0 0 1 netrin receptor activity 5041 3 0 0 1 0.4488 low-density lipoprotein receptor activity 17005 1 0 0 0 1 tyrosyl-DNA phosophodiesterase activity 5037 2 0 0 1 0.3277 death receptor adaptor protein activity 5035 5 0 0 0 1 death receptor activity 5034 1 0 0 0 1 osmosensor activity 5032 1 0 0 0 1 "tumor necrosis factor receptor cell differentiation, type I" 5031 4 0 0 0 1 tumor necrosis factor receptor activity 5027 4 0 0 0 1 NGF/TNF (6 C-domain) receptor activity 5024 12 0 0 2 1 transforming growth factor-beta receptor activity 5021 1 0 0 0 1 vascular endothelial growth factor receptor activity 5010 1 0 0 0 1 insulin-like growth factor receptor activity 5008 1 0 0 0 1 hepatocyte growth factor receptor activity 5007 4 0 0 2 0.1509 fibroblast growth factor receptor activity 5006 4 0 0 1 0.5481 epidermal growth factor receptor activity 5005 3 0 0 0 1 transmembrane-ephrin receptor activity 5003 11 0 0 0 1 ephrin receptor activity 5001 1 0 0 1 0.18 transmembrane receptor protein tyrosine phosphatase activity 5000 4 0 0 1 0.5481 vasopressin receptor activity 16597 2 0 0 0 1 amino acid binding 8970 1 0 0 1 0.18 phospholipase A1 activity 16566 2 0 0 0 1 specific transcriptional repressor activity 16565 1 0 0 0 1 general transcriptional repressor activity 16564 29 0 0 6 0.6332 transcriptional repressor activity 16563 30 0 0 6 0.811 transcriptional activator activity 4598 1 0 0 0 1 peptidylamidoglycolate lyase activity 4597 1 0 0 0 1 peptide-aspartate beta-dioxygenase activity 4596 3 0 0 1 0.4488 peptide alpha-N-acetyltransferase activity 4594 2 0 0 2 0.0324 pantothenate kinase activity 4591 1 0 0 0 1 oxoglutarate dehydrogenase (lipoamide) activity 4590 1 0 0 0 1 orotidine-5'-phosphate decarboxylase activity 8943 2 0 0 1 0.3277 glyceraldehyde 3-phosphate dehydrogenase activity 4588 1 0 0 0 1 orotate phosphoribosyltransferase activity 4587 1 0 0 0 1 ornithine-oxo-acid aminotransferase activity 4586 1 0 0 0 1 ornithine decarboxylase activity 4585 1 0 0 0 1 ornithine carbamoyltransferase activity 4582 1 0 0 1 0.18 dolichyl-phosphate beta-D-mannosyltransferase activity 4581 1 0 0 1 0.18 dolichyl-phosphate beta-glucosyltransferase activity 8937 1 0 0 0 1 ferredoxin reductase activity 8934 2 0 0 1 0.0206 myo-inositol-1(or 4)-monophosphatase activity 16541 1 0 0 0 1 intein 4579 2 0 0 2 0.0324 dolichyl-diphospho-oligosaccharide-protein glycosyltransferase activity 4576 3 0 0 2 0.0855 oligosaccharyl transferase activity 4572 1 0 0 0 1 "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity" 16538 31 0 0 6 0.8153 "cyclin-dependent protein kinase, regulator activity" 16534 1 0 0 0 1 cyclin-dependent protein kinase 5 activator activity 16532 1 0 0 0 1 superoxide dismutase copper chaperone activity 16531 1 0 0 0 1 copper chaperone activity 16530 1 0 0 0 1 metallochaperone activity 4568 1 0 0 0 1 chitinase activity 4566 2 0 0 1 0.3277 beta-glucuronidase activity 4565 2 0 0 0 1 beta-galactosidase activity 4563 2 0 0 1 0.3277 beta-N-acetylhexosaminidase activity 16527 3 0 0 0 1 brain-specific angiogenesis inhibitor activity 16526 15 0 0 1 0.4965 "G-protein coupled receptor activity, unknown ligand" 16520 1 0 0 0 1 growth hormone-releasing hormone receptor activity 4559 3 0 0 1 0.4488 alpha-mannosidase activity 4558 3 0 0 0 1 alpha-glucosidase activity 4557 2 0 0 0 1 alpha-galactosidase activity 4556 3 0 0 0 1 alpha-amylase activity 4555 1 0 0 0 1 "alpha,alpha-trehalase activity" 4553 36 0 0 6 1 "hydrolase activity, hydrolyzing O-glycosyl compounds" 4551 2 0 0 0 1 nucleotide pyrophosphatase activity 4550 8 0 0 3 0.1608 nucleoside-diphosphate kinase activity 8907 1 0 0 0 1 integrase activity 16511 2 0 0 0 1 endothelin-converting enzyme activity 16510 1 0 0 1 0.18 short-chain enoyl-CoA hydratase activity 4549 4 0 0 1 0.5481 tRNA-specific ribonuclease activity 8900 3 0 0 1 0.4488 hydrogen/potassium-exchanging ATPase activity 4540 20 0 0 2 0.5591 ribonuclease activity 182 1 0 0 1 0.18 ribosomal DNA (rDNA) binding 16509 1 0 0 0 1 long-chain 3-hydroxyacyl-CoA dehydrogenase activity 16508 1 0 0 1 0.18 long-chain enoyl-CoA hydratase activity 16506 11 0 0 2 1 apoptosis activator activity 16505 2 0 0 0 1 apoptotic protease activator activity 16504 2 0 0 0 1 protease activator activity 16502 34 0 0 0 1 nucleotide receptor activity 16500 5 0 0 0 1 protein-hormone receptor activity 4536 9 0 0 0 1 deoxyribonuclease activity 4532 7 0 0 0 1 exoribonuclease activity 179 2 0 0 2 0.0324 "rRNA (adenine-N6,N6-)-dimethyltransferase activity" 4530 2 0 0 0 1 deoxyribonuclease I activity 175 7 0 0 0 1 3'-5' exoribonuclease activity 171 5 0 0 2 0.2224 ribonuclease MRP activity 4529 1 0 0 0 1 exodeoxyribonuclease activity 4528 2 0 0 0 1 phosphodiesterase I activity 4527 22 0 0 0 1 exonuclease activity 4526 4 0 0 1 0.5481 ribonuclease P activity 4525 1 0 0 0 1 ribonuclease III activity 4524 1 0 0 0 1 ribonuclease H1 activity 4523 1 0 0 0 1 ribonuclease H activity 4522 5 0 0 0 1 pancreatic ribonuclease activity 4521 12 0 0 1 0.7058 endoribonuclease activity 4520 8 0 0 0 1 endodeoxyribonuclease activity 166 1003 0 0 200 0.0898 nucleotide binding 163 11 0 0 3 0.429 protein phosphatase type 1 activity 4519 36 0 0 3 0.1886 endonuclease activity 4518 56 0 0 4 0.0346 nuclease activity 4517 2 0 0 0 1 nitric oxide synthase activity 4511 1 0 0 0 1 tyrosine 3-monooxygenase activity 158 13 0 0 5 0.0679 protein phosphatase type 2A activity 156 1 0 0 0 1 two-component response regulator activity 155 4 0 0 0 1 two-component sensor molecule activity 150 2 0 0 0 1 recombinase activity 4508 1 0 0 0 1 steroid 17-alpha-monooxygenase activity 4506 1 0 0 1 0.18 squalene monooxygenase activity 4505 1 0 0 0 1 phenylalanine 4-monooxygenase activity 4504 1 0 0 0 1 peptidyl-glycine monooxygenase activity 4503 1 0 0 0 1 monophenol monooxygenase activity 149 5 0 0 0 1 SNARE binding 4500 1 0 0 0 1 dopamine-beta-monooxygenase activity 146 1 0 0 0 1 microfilament motor activity 106 1 0 0 0 1 biotin-apoprotein ligase activity 104 1 0 0 1 0.18 succinate dehydrogenase activity 100 1 0 0 0 1 S-methylmethionine transporter activity 9384 1 0 0 0 1 N-acylmannosamine kinase activity 9374 3 0 0 1 0.4488 biotin binding 8898 2 0 0 0 1 homocysteine S-methyltransferase activity 8897 1 0 0 0 1 holo-[acyl-carrier protein] synthase activity 16499 1 0 0 0 1 orexin receptor activity 16494 5 0 0 0 1 C-X-C chemokine receptor activity 16493 12 0 0 0 1 C-C chemokine receptor activity 16492 2 0 0 1 0.3277 "neurotensin receptor activity, G-protein coupled" 16491 312 0 0 107 0 oxidoreductase activity 48029 3 0 0 0 1 monosaccharide binding 42708 2 0 0 0 1 elastase activity 16462 4 0 0 0 1 pyrophosphatase activity 4499 5 0 0 0 1 dimethylaniline monooxygenase (N-oxide forming) activity 4497 38 0 0 5 0.5304 monooxygenase activity 4496 1 0 0 1 0.18 mevalonate kinase activity 4494 1 0 0 0 1 methylmalonyl-CoA mutase activity 4492 1 0 0 0 1 methylmalonyl-CoA decarboxylase activity 4491 1 0 0 0 1 methylmalonate-semialdehyde dehydrogenase (acylating) activity 16455 6 0 0 1 1 RNA polymerase II transcription mediator activity 16454 2 0 0 0 1 C-palmitoyltransferase activity 16453 4 0 0 3 0.0202 C-acetyltransferase activity 16452 2 0 0 0 1 theta DNA polymerase activity 16451 3 0 0 0 1 nu DNA polymerase activity 16450 2 0 0 0 1 kappa DNA polymerase activity 4489 1 0 0 0 1 methylenetetrahydrofolate reductase (NADPH) activity 4488 2 0 0 0 1 methylenetetrahydrofolate dehydrogenase (NADP+) activity 4486 2 0 0 0 1 methylenetetrahydrofolate dehydrogenase activity 4485 1 0 0 1 0.18 methylcrotonyl-CoA carboxylase activity 4484 1 0 0 0 1 mRNA guanylyltransferase activity 16449 2 0 0 0 1 lambda DNA polymerase activity 16448 2 0 0 0 1 mu DNA polymerase activity 4478 1 0 0 0 1 methionine adenosyltransferase activity 4477 2 0 0 0 1 methenyltetrahydrofolate cyclohydrolase activity 4476 1 0 0 0 1 mannose-6-phosphate isomerase activity 4471 1 0 0 0 1 malate dehydrogenase (decarboxylating) activity 4470 3 0 0 2 0.0855 malic enzyme activity 16433 2 0 0 2 0.0324 rRNA (adenine) methyltransferase activity 4467 4 0 0 1 0.5481 long-chain-fatty-acid-CoA-ligase activity 4466 1 0 0 0 1 long-chain acyl-CoA dehydrogenase activity 4465 1 0 0 0 1 lipoprotein lipase activity 4464 1 0 0 0 1 leukotriene-C4 synthase activity 4463 3 0 0 2 0.0855 leukotriene-A4 hydrolase activity 4462 1 0 0 1 0.18 lactoylglutathione lyase activity 4461 2 0 0 0 1 lactose synthase activity 16421 3 0 0 1 0.4488 CoA carboxylase activity 4459 2 0 0 2 0.0324 L-lactate dehydrogenase activity 4457 2 0 0 2 0.0324 lactate dehydrogenase activity 4454 1 0 0 0 1 ketohexokinase activity 4452 1 0 0 0 1 isopentenyl-diphosphate delta-isomerase activity 4451 1 0 0 0 1 isocitrate lyase activity 99 1 0 0 0 1 sulfur amino acid transporter activity 4450 3 0 0 2 0.0855 isocitrate dehydrogenase (NADP+) activity 16418 1 0 0 0 1 S-acetyltransferase activity 16417 1 0 0 0 1 S-acyltransferase activity 16416 2 0 0 0 1 O-palmitoyltransferase activity 16415 1 0 0 0 1 octanoyltransferase activity 16414 1 0 0 0 1 O-octanoyltransferase activity 16413 4 0 0 0 1 O-acetyltransferase activity 16411 3 0 0 1 0.4488 acylglycerol O-acyltransferase activity 16410 15 0 0 3 0.7421 N-acyltransferase activity 4449 5 0 0 2 0.2224 isocitrate dehydrogenase (NAD+) activity 4448 6 0 0 3 0.0758 isocitrate dehydrogenase activity 4447 1 0 0 0 1 iodide peroxidase activity 4445 2 0 0 0 1 "inositol-1,4,5-trisphosphate 5-phosphatase activity" 4441 2 0 0 1 0.3277 "inositol-1,4-bisphosphate 1-phosphatase activity" 16409 4 0 0 0 1 palmitoyltransferase activity 16408 8 0 0 3 0.1608 C-acyltransferase activity 16407 27 0 0 9 0.0457 acetyltransferase activity 16406 4 0 0 0 1 carnitine O-acyltransferase activity 16405 3 0 0 1 0.4488 CoA-ligase activity 16404 1 0 0 1 0.0103 15-hydroxyprostaglandin dehydrogenase (NAD+) activity 16403 2 0 0 1 0.3277 dimethylargininase activity 16402 1 0 0 0 1 pristanoyl-CoA oxidase activity 4439 1 0 0 1 0.18 phosphatidylinositol-bisphosphatase activity 4438 1 0 0 0 1 phosphatidylinositol-3-phosphatase activity 4437 16 0 0 3 1 inositol/phosphatidylinositol phosphatase activity 4435 7 0 0 0 1 "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" 4434 7 0 0 0 1 inositol/phosphatidylinositol phosphodiesterase activity 4430 1 0 0 0 1 1-phosphatidylinositol 4-kinase activity 4428 19 0 0 0 1 inositol/phosphatidylinositol kinase activity 4427 2 0 0 0 1 inorganic diphosphatase activity 4426 1 0 0 0 1 "indoleamine-pyrrole 2,3-dioxygenase activity" 4423 1 0 0 0 1 iduronate-2-sulfatase activity 4421 3 0 0 0 1 hydroxymethylglutaryl-CoA synthase activity 4420 1 0 0 0 1 hydroxymethylglutaryl-CoA reductase (NADPH) activity 62 3 0 0 1 0.4488 acyl-CoA binding 4419 1 0 0 1 0.18 hydroxymethylglutaryl-CoA lyase activity 4418 1 0 0 0 1 hydroxymethylbilane synthase activity 4416 1 0 0 0 1 hydroxyacylglutathione hydrolase activity 4415 3 0 0 0 1 hyaluronoglucosaminidase activity 4411 1 0 0 0 1 "homogentisate 1,2-dioxygenase activity" 4408 1 0 0 0 1 holocytochrome c synthase activity 4407 11 0 0 1 0.701 histone deacetylase activity 4406 1 0 0 1 0.18 H3/H4 histone acetyltransferase activity 4402 8 0 0 3 0.1608 histone acetyltransferase activity 49 5 0 0 3 0.0437 tRNA binding 48 2 0 0 0 1 peptidyltransferase activity 15999 2 0 0 0 1 eta DNA polymerase activity 15997 1 0 0 0 1 ubiquinone biosynthesis monooxygenase activity 36 2 0 0 1 0.3277 acyl carrier activity 30 1 0 0 1 0.18 mannosyltransferase activity 14 2 0 0 0 1 single-stranded DNA specific endodeoxyribonuclease activity 3999 1 0 0 1 0.18 adenine phosphoribosyltransferase activity 3998 2 0 0 0 1 acylphosphatase activity 3997 3 0 0 0 1 acyl-CoA oxidase activity 3995 8 0 0 1 1 acyl-CoA dehydrogenase activity 5 2 0 0 0 1 ribosomal chaperone activity 3994 2 0 0 0 1 aconitate hydratase activity 3993 8 0 0 0 1 acid phosphatase activity 3990 2 0 0 0 1 acetylcholinesterase activity 3988 4 0 0 1 0.5481 acetyl-CoA C-acyltransferase activity 3987 2 0 0 1 0.3277 acetate-CoA ligase activity 3985 4 0 0 3 0.0202 acetyl-CoA C-acetyltransferase activity 3983 1 0 0 1 0.18 UTP-glucose-1-phosphate uridylyltransferase activity 3982 1 0 0 0 1 UTP-hexose-1-phosphate uridylyltransferase activity 3979 1 0 0 0 1 UDP-glucose 6-dehydrogenase activity 3978 1 0 0 0 1 UDP-glucose 4-epimerase activity 3977 1 0 0 1 0.18 UDP-N-acetylglucosamine pyrophosphorylase activity 3975 1 0 0 1 0.18 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity 3973 2 0 0 0 1 (S)-2-hydroxy-acid oxidase activity 15932 4 0 0 0 1 "nucleobase, nucleoside, nucleotide and nucleic acid transporter activity" 3969 5 0 0 1 1 RNA editase activity 3964 1 0 0 0 1 RNA-directed DNA polymerase activity 3960 2 0 0 0 1 NADPH:quinone reductase activity 15929 5 0 0 1 1 hexosaminidase activity 15927 1 0 0 0 1 trehalase activity 15926 4 0 0 0 1 glucosidase activity 15925 4 0 0 0 1 galactosidase activity 15924 1 0 0 0 1 mannosyl-oligosaccharide mannosidase activity 15923 3 0 0 1 0.4488 mannosidase activity 3959 1 0 0 0 1 NADPH dehydrogenase activity 3958 1 0 0 1 0.18 NADPH-ferrihemoprotein reductase activity 3957 1 0 0 0 1 NAD(P)+ transhydrogenase (B-specific) activity 3956 2 0 0 0 1 NAD(P)+-arginine ADP-ribosyltransferase activity 3955 2 0 0 2 0.0324 NAD(P)H dehydrogenase (quinone) activity 3954 10 0 0 6 0.0036 NADH dehydrogenase activity 3953 2 0 0 0 1 NAD+ nucleosidase activity 3950 2 0 0 0 1 NAD+ ADP-ribosyltransferase activity 3948 1 0 0 0 1 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity 3945 3 0 0 0 1 N-acetyllactosamine synthase activity 3943 1 0 0 0 1 N-acetylgalactosamine-4-sulfatase activity 3941 1 0 0 0 1 L-serine ammonia-lyase activity 3940 1 0 0 0 1 L-iduronidase activity 3939 1 0 0 1 0.18 L-iditol 2-dehydrogenase activity 3938 2 0 0 1 0.3277 IMP dehydrogenase activity 3937 1 0 0 1 0.18 IMP cyclohydrolase activity 3932 1 0 0 1 0.18 SAR small monomeric GTPase activity 3931 15 0 0 5 0.1673 Rho small monomeric GTPase activity 3930 10 0 0 2 0.6983 RAS small monomeric GTPase activity 3929 1 0 0 1 0.18 RAN small monomeric GTPase activity 3928 23 0 0 4 1 RAB small monomeric GTPase activity 3927 31 0 0 7 0.4839 heterotrimeric G-protein GTPase activity 3926 5 0 0 2 0.2224 ARF small monomeric GTPase activity 3925 63 0 0 15 0.2472 small monomeric GTPase activity 3924 111 0 0 29 0.0332 GTPase activity 3923 1 0 0 1 0.18 GPI-anchor transamidase activity 3920 2 0 0 0 1 GMP reductase activity 3918 5 0 0 1 1 DNA topoisomerase type II activity 3917 3 0 0 1 0.4488 DNA topoisomerase type I activity 3916 9 0 0 2 0.6688 DNA topoisomerase activity 3913 1 0 0 0 1 DNA photolyase activity 3912 1 0 0 0 1 DNA nucleotidylexotransferase activity 3910 3 0 0 0 1 DNA ligase (ATP) activity 3909 3 0 0 0 1 DNA ligase activity 3908 2 0 0 0 1 methylated-DNA-[protein]-cysteine S-methyltransferase activity 3906 3 0 0 1 0.4488 DNA-(apurinic or apyrimidinic site) lyase activity 3905 1 0 0 0 1 alkylbase DNA N-glycosylase activity 30695 106 0 0 14 0.2503 GTPase regulator activity 8796 2 0 0 0 1 bis(5'-nucleosyl)-tetraphosphatase activity 8794 1 0 0 0 1 arsenate reductase (glutaredoxin) activity 8781 1 0 0 0 1 acylneuraminate cytidylyltransferase activity 42626 102 0 0 33 0.0004 "ATPase activity, coupled to transmembrane movement of substances" 42625 58 0 0 24 0 "ATPase activity, coupled to transmembrane movement of ions" 42623 153 0 0 43 0.0019 "ATPase activity, coupled" 8757 26 0 0 5 0.8004 S-adenosylmethionine-dependent methyltransferase activity 42607 2 0 0 0 1 exogenous peptide antigen binding 42605 2 0 0 0 1 peptide antigen binding 8750 1 0 0 0 1 NAD(P)+ transhydrogenase (AB-specific) activity 4398 1 0 0 0 1 histidine decarboxylase activity 4397 1 0 0 0 1 histidine ammonia-lyase activity 4396 5 0 0 0 1 hexokinase activity 4395 1 0 0 0 1 hexaprenyldihydroxybenzoate methyltransferase activity 4394 2 0 0 0 1 heparin-sulfate 2-sulfotransferase activity 4393 2 0 0 0 1 heparin N-deacetylase/N-sulfotransferase activity 4392 3 0 0 0 1 heme oxygenase (decyclizing) activity 8746 1 0 0 0 1 NAD(P)+ transhydrogenase activity 4386 53 0 0 13 0.2106 helicase activity 4385 7 0 0 1 1 guanylate kinase activity 4383 11 0 0 0 1 guanylate cyclase activity 4381 1 0 0 0 1 glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity 4380 1 0 0 0 1 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity 16343 1 0 0 0 1 cytoskeletal anchor protein activity 4379 2 0 0 0 1 glycyl-peptide N-tetradecanoyltransferase activity 4375 1 0 0 0 1 glycine dehydrogenase (decarboxylating) activity 30618 1 0 0 0 1 "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" 4373 1 0 0 0 1 glycogen (starch) synthase activity 4372 6 0 0 2 0.2957 glycine hydroxymethyltransferase activity 30614 1 0 0 0 1 "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor" 30613 1 0 0 0 1 "oxidoreductase activity, acting on phosphorus or arsenic in donors" 30612 3 0 0 1 0.4488 arsenate reductase (thioredoxin) activity 30611 4 0 0 1 0.5481 arsenate reductase activity 4368 1 0 0 0 1 glycerol-3-phosphate dehydrogenase activity 4367 2 0 0 0 1 glycerol-3-phosphate dehydrogenase (NAD+) activity 4365 2 0 0 1 0.3277 glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) activity 4364 11 0 0 4 0.1197 glutathione transferase activity 4363 1 0 0 1 0.18 glutathione synthase activity 4362 1 0 0 0 1 glutathione reductase (NADPH) activity 4361 1 0 0 0 1 glutaryl-CoA dehydrogenase activity 4360 2 0 0 0 1 glucosamine-fructose-6-phosphate aminotransferase (isomerizing) activity 16329 61 0 0 14 0.3151 apoptosis regulator activity 16326 6 0 0 1 1 kinesin motor activity 4359 1 0 0 0 1 glutaminase activity 4357 2 0 0 2 0.0001 glutamate-cysteine ligase activity 4356 1 0 0 1 0.18 glutamate-ammonia ligase activity 4353 1 0 0 0 1 glutamate dehydrogenase (NAD(P)+) activity 4351 2 0 0 0 1 glutamate decarboxylase activity 4350 1 0 0 0 1 glutamate-5-semialdehyde dehydrogenase activity 16316 1 0 0 0 1 "inositol-3,4-bisphosphate 4-phosphatase activity" 8705 1 0 0 0 1 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity 16314 1 0 0 0 1 "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity" 16312 3 0 0 1 0.4488 inositol bisphosphate phosphatase activity 4349 1 0 0 0 1 glutamate 5-kinase activity 4348 1 0 0 0 1 glucosylceramidase activity 4347 1 0 0 1 0.18 glucose-6-phosphate isomerase activity 4346 1 0 0 0 1 glucose-6-phosphatase activity 4342 1 0 0 0 1 glucosamine-6-phosphate deaminase activity 4340 1 0 0 0 1 glucokinase activity 16308 5 0 0 0 1 1-phosphatidylinositol-4-phosphate 5-kinase activity 16307 6 0 0 0 1 phosphatidylinositol phosphate kinase activity 16303 7 0 0 0 1 phosphatidylinositol 3-kinase activity 16301 498 0 0 68 0.0076 kinase activity 4337 1 0 0 1 0.18 geranyltranstransferase activity 4336 1 0 0 1 0.18 galactosylceramidase activity 4335 1 0 0 0 1 galactokinase activity 4334 1 0 0 0 1 fumarylacetoacetase activity 4332 3 0 0 1 0.4488 fructose-bisphosphate aldolase activity 4331 3 0 0 0 1 "fructose-2,6-bisphosphate 2-phosphatase activity" 4329 1 0 0 0 1 formate-tetrahydrofolate ligase activity 4326 1 0 0 0 1 folylpolyglutamate synthase activity 4325 1 0 0 0 1 ferrochelatase activity 4324 1 0 0 0 1 ferredoxin-NADP reductase activity 4322 1 0 0 1 0.18 ferroxidase activity 4312 1 0 0 0 1 fatty-acid synthase activity 4311 2 0 0 1 0.3277 farnesyltranstransferase activity 4310 1 0 0 1 0.18 farnesyl-diphosphate farnesyltransferase activity 4308 1 0 0 0 1 exo-alpha-sialidase activity 4307 1 0 0 0 1 ethanolaminephosphotransferase activity 4305 1 0 0 0 1 ethanolamine kinase activity 4304 1 0 0 0 1 estrone sulfotransferase activity 4303 4 0 0 0 1 estradiol 17 beta-dehydrogenase activity 4301 2 0 0 1 0.3277 epoxide hydrolase activity 4300 3 0 0 1 0.4488 enoyl-CoA hydratase activity 3899 11 0 0 4 0.1197 DNA-directed RNA polymerase activity 3896 1 0 0 0 1 DNA primase activity 3895 4 0 0 0 1 gamma DNA-directed DNA polymerase activity 3894 3 0 0 0 1 zeta DNA polymerase activity 3893 2 0 0 0 1 epsilon DNA polymerase activity 3891 4 0 0 0 1 delta DNA polymerase activity 3890 2 0 0 0 1 beta DNA polymerase activity 3889 2 0 0 0 1 alpha DNA polymerase activity 3887 16 0 0 0 1 DNA-directed DNA polymerase activity 3886 2 0 0 0 1 DNA (cytosine-5-)-methyltransferase activity 3883 2 0 0 0 1 CTP synthase activity 3882 1 0 0 0 1 CDP-diacylglycerol-serine O-phosphatidyltransferase activity 3881 1 0 0 0 1 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity 3880 2 0 0 0 1 C-terminal protein carboxyl methyltransferase activity 3879 1 0 0 0 1 ATP phosphoribosyltransferase activity 3878 1 0 0 0 1 ATP citrate synthase activity 3876 4 0 0 0 1 AMP deaminase activity 3875 1 0 0 0 1 ADP-ribosylarginine hydrolase activity 3874 1 0 0 1 0.0103 6-pyruvoyltetrahydropterin synthase activity 3873 2 0 0 0 1 6-phosphofructo-2-kinase activity 3872 3 0 0 3 0.0058 6-phosphofructokinase activity 3870 2 0 0 0 1 5-aminolevulinate synthase activity 3868 1 0 0 0 1 4-hydroxyphenylpyruvate dioxygenase activity 3865 2 0 0 0 1 3-oxo-5-alpha-steroid 4-dehydrogenase activity 3863 2 0 0 0 1 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity 3860 1 0 0 0 1 3-hydroxyisobutyryl-CoA hydrolase activity 3858 1 0 0 0 1 3-hydroxybutyrate dehydrogenase activity 3857 2 0 0 1 0.3277 3-hydroxyacyl-CoA dehydrogenase activity 3854 2 0 0 0 1 3-beta-hydroxy-delta(5)-steroid dehydrogenase activity 3851 1 0 0 0 1 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity 3847 4 0 0 1 0.5481 2-acetyl-1-alkylglycerophosphocholine esterase activity 3845 2 0 0 0 1 11-beta-hydroxysteroid dehydrogenase activity 3844 1 0 0 0 1 "1,4-alpha-glucan branching enzyme activity" 3841 2 0 0 1 0.3277 1-acylglycerol-3-phosphate O-acyltransferase activity 3840 3 0 0 0 1 gamma-glutamyl transferase activity 3837 1 0 0 0 1 beta-ureidopropionase activity 3836 2 0 0 0 1 "beta-galactoside alpha-2,3-sialyltransferase activity" 3835 1 0 0 1 0.18 "beta-galactosamide alpha-2,6-sialyltransferase activity" 3834 2 0 0 0 1 "beta-carotene 15,15'-dioxygenase activity" 3832 1 0 0 0 1 beta-alanyl-dopamine hydrolase activity 3831 3 0 0 0 1 "beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase activity" 3830 1 0 0 0 1 "beta-1,4-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" 3829 2 0 0 0 1 "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" 3828 5 0 0 0 1 "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" 3827 1 0 0 1 0.18 "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" 3826 1 0 0 0 1 alpha-ketoacid dehydrogenase activity 3825 1 0 0 0 1 "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity" 3824 2356 0 0 474 0.0009 catalytic activity 3823 23 0 0 1 0.1041 antigen binding 3813 1 0 0 0 1 classical-complement pathway C3/C5 convertase activity 3812 1 0 0 1 0.18 alternative-complement pathway C3/C5 convertase activity 3811 17 0 0 2 0.7532 complement activity 3810 4 0 0 1 0.5481 protein-glutamine gamma-glutamyltransferase activity 3809 3 0 0 0 1 thrombin activity 3808 1 0 0 0 1 protein C (activated) activity 3807 1 0 0 0 1 plasma kallikrein activity 3803 1 0 0 0 1 blood coagulation factor IX activity 3802 1 0 0 0 1 blood coagulation factor VII activity 3801 16 0 0 0 1 blood coagulation factor activity 46943 42 0 0 3 0.07 carboxylic acid transporter activity 46935 1 0 0 0 1 phosphatidylinositol 3-kinase regulator activity 42578 161 0 0 19 0.0376 phosphoric ester hydrolase activity 42577 4 0 0 1 0.5481 lipid phosphatase activity 46923 2 0 0 0 1 ER retention sequence binding 42562 1 0 0 0 1 hormone binding 30594 38 0 0 0 1 neurotransmitter receptor activity 46915 6 0 0 1 1 transition metal ion transporter activity 46914 177 0 0 36 0.4273 transition metal ion binding 46912 1 0 0 0 1 "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" 46906 3 0 0 1 0.4488 tetrapyrrole binding 16299 1 0 0 0 1 regulator of G-protein signaling activity 16298 34 0 0 6 1 lipase activity 16291 1 0 0 0 1 acyl-CoA thioesterase activity 16289 2 0 0 0 1 CoA hydrolase activity 16286 4 0 0 0 1 small conductance calcium-activated potassium channel activity 16285 1 0 0 1 0.18 cytosol alanyl aminopeptidase activity 16284 5 0 0 3 0.0437 alanine aminopeptidase activity 8670 1 0 0 1 0.18 "2,4-dienoyl-CoA reductase (NADPH) activity" 30554 888 0 0 168 0.4525 adenyl nucleotide binding 30553 5 0 0 0 1 "3',5'-cGMP binding" 30552 8 0 0 1 1 "3',5'-cAMP binding" 30551 13 0 0 1 0.4854 cyclic nucleotide binding 16279 2 0 0 1 0.3277 protein-lysine N-methyltransferase activity 16278 2 0 0 1 0.3277 lysine N-methyltransferase activity 8665 1 0 0 1 0.18 2'-phosphotransferase activity 8656 2 0 0 0 1 caspase activator activity 8651 2 0 0 0 1 actin polymerizing activity 4299 16 0 0 11 0 proteasome endopeptidase activity 4297 1 0 0 0 1 U-plasminogen activator activity 4296 1 0 0 0 1 T-plasminogen activator activity 4295 58 0 0 5 0.0603 trypsin activity 4294 1 0 0 0 1 tripeptidyl-peptidase II activity 4293 5 0 0 1 1 tissue kallikrein activity 8649 2 0 0 2 0.0324 rRNA methyltransferase activity 8648 1 0 0 0 1 tachykinin 16251 25 0 0 4 1 general RNA polymerase II transcription factor activity 8642 2 0 0 0 1 ubiquitin-like activating enzyme activity 8641 2 0 0 0 1 small protein activating enzyme activity 4289 15 0 0 0 1 subtilase activity 4287 4 0 0 0 1 prolyl oligopeptidase activity 4286 1 0 0 0 1 proprotein convertase 2 activity 4285 1 0 0 0 1 proprotein convertase 1 activity 30528 622 0 0 56 0 transcription regulator activity 4284 1 0 0 0 1 acrosin activity 4283 1 0 0 0 1 plasmin activity 4281 1 0 0 0 1 pancreatic elastase II activity 30523 1 0 0 0 1 dihydrolipoamide S-acyltransferase activity 8639 19 0 0 9 0.0031 small protein conjugating enzyme activity 16247 4 0 0 0 1 channel regulator activity 8638 2 0 0 1 0.3277 protein tagging activity 4278 1 0 0 0 1 granzyme B activity 4277 1 0 0 0 1 granzyme A activity 4276 1 0 0 0 1 furin activity 4275 1 0 0 0 1 enteropeptidase activity 30519 1 0 0 0 1 snoRNP binding 4274 3 0 0 0 1 dipeptidyl-peptidase IV activity 30515 4 0 0 1 0.5481 snoRNA binding 4263 49 0 0 4 0.0906 chymotrypsin activity 4261 1 0 0 0 1 cathepsin G activity 16229 8 0 0 0 1 steroid dehydrogenase activity 16228 5 0 0 4 0.0045 aldolase activity 16225 2 0 0 0 1 cysteine desulfhydrase activity 16220 1 0 0 0 1 RAL GDP-dissociation stimulator activity 4254 1 0 0 0 1 acylaminoacyl-peptidase activity 4252 93 0 0 7 0.0061 serine-type endopeptidase activity 4251 1 0 0 0 1 Xaa-Pro dipeptidase activity 4250 1 0 0 1 0.18 aminopeptidase I activity 16219 1 0 0 0 1 GDP-dissociation stimulator activity 8606 1 0 0 0 1 "phosphorylase kinase, catalyst activity" 16215 2 0 0 1 0.3277 CoA desaturase activity 8605 1 0 0 1 0.18 "protein kinase CK2, regulator activity" 8604 1 0 0 0 1 "protein kinase CK2, catalyst activity" 8603 7 0 0 2 0.6168 "cAMP-dependent protein kinase, regulator activity" 8602 1 0 0 0 1 "cAMP-dependent protein kinase, catalyst activity" 16211 3 0 0 1 0.4488 ammonia ligase activity 8601 5 0 0 2 0.2224 "protein phosphatase type 2A, regulator activity" 4249 1 0 0 0 1 stromelysin 3 activity 8600 2 0 0 2 0.0324 "protein phosphatase type 2A, catalyst activity" 4248 1 0 0 0 1 stromelysin 1 activity 4246 2 0 0 0 1 peptidyl-dipeptidase A activity 4245 4 0 0 0 1 neprilysin activity 4243 1 0 0 0 1 mitochondrial intermediate peptidase activity 4240 1 0 0 0 1 mitochondrial processing peptidase activity 16209 9 0 0 10 0 antioxidant activity 16208 8 0 0 1 1 AMP binding 4239 4 0 0 0 1 methionyl aminopeptidase activity 4238 2 0 0 0 1 meprin A activity 4237 2 0 0 0 1 membrane dipeptidase activity 4235 1 0 0 0 1 matrilysin activity 4234 1 0 0 0 1 macrophage elastase activity 4232 1 0 0 0 1 interstitial collagenase activity 4231 1 0 0 1 0.18 insulysin activity 4230 1 0 0 0 1 glutamyl aminopeptidase activity 4229 1 0 0 0 1 gelatinase B activity 4228 1 0 0 0 1 gelatinase A activity 4226 1 0 0 0 1 gly-X carboxypeptidase activity 4222 70 0 0 9 0.3468 metalloendopeptidase activity 4221 19 0 0 4 0.7636 ubiquitin C-terminal hydrolase activity 4218 1 0 0 0 1 cathepsin S activity 4217 1 0 0 1 0.18 cathepsin L activity 4216 1 0 0 0 1 cathepsin K activity 4215 1 0 0 1 0.18 cathepsin H activity 4214 1 0 0 2 0.0855 dipeptidyl-peptidase I activity 4213 1 0 0 1 0.18 cathepsin B activity 4208 1 0 0 0 1 caspase-3 activity 4205 1 0 0 0 1 caspase-8 activity 4201 1 0 0 1 0.18 caspase-1 activity 3799 1 0 0 0 1 antifungal peptide activity 3797 3 0 0 1 0.4488 antibacterial peptide activity 3796 1 0 0 1 0.18 lysozyme activity 3795 7 0 0 2 0.6168 antimicrobial peptide activity 3794 3 0 0 0 1 acute-phase response protein activity 3793 71 0 0 7 0.0862 defense/immunity protein activity 3792 1 0 0 0 1 regulation of actin thin filament length activity 3790 1 0 0 0 1 actin modulating activity 3789 2 0 0 1 0.3277 actin filament severing activity 3788 1 0 0 1 0.18 actin monomer sequestering activity 3786 2 0 0 0 1 actin lateral binding 3785 1 0 0 1 0.18 actin monomer binding 3784 1 0 0 1 0.18 barbed-end actin capping/severing activity 3782 7 0 0 2 0.6168 F-actin capping activity 3781 4 0 0 0 1 actin bundling activity 3780 2 0 0 0 1 actin cross-linking activity 3779 120 0 0 22 0.9047 actin binding 3777 23 0 0 3 0.7855 microtubule motor activity 3776 1 0 0 0 1 muscle motor activity 3774 52 0 0 3 0.0176 motor activity 3773 29 0 0 16 0 heat shock protein activity 3767 4 0 0 0 1 co-chaperone activity 3763 1 0 0 0 1 chaperonin ATPase activity 3762 1 0 0 0 1 histone-specific chaperone activity 3756 3 0 0 2 0.0855 protein disulfide isomerase activity 3755 25 0 0 9 0.032 peptidyl-prolyl cis-trans isomerase activity 3754 80 0 0 34 0 chaperone activity 9055 17 0 0 3 1 electron carrier activity 3747 1 0 0 0 1 translation release factor activity 3746 18 0 0 7 0.0304 translation elongation factor activity 3743 32 0 0 19 0 translation initiation factor activity 9045 1 0 0 0 1 xylose isomerase activity 3735 136 0 0 84 0 structural constituent of ribosome 3730 1 0 0 1 0.18 mRNA 3' UTR binding 46873 22 0 0 9 0.0101 metal ion transporter activity 46872 532 0 0 107 0.1953 metal ion binding 3729 40 0 0 19 0 mRNA binding 3727 3 0 0 1 0.4488 single-stranded RNA binding 3726 3 0 0 1 0.4488 double-stranded RNA adenosine deaminase activity 3725 11 0 0 4 0.1197 double-stranded RNA binding 3724 11 0 0 3 0.429 RNA helicase activity 3723 223 0 0 102 0 RNA binding 3721 1 0 0 0 1 telomeric template RNA reverse transcriptase activity 3720 1 0 0 0 1 telomerase activity 3719 1 0 0 0 1 "transcription factor binding, cytoplasmic sequestering" 3714 22 0 0 2 0.406 transcription co-repressor activity 3713 26 0 0 5 0.8004 transcription co-activator activity 3712 59 0 0 10 1 transcription cofactor activity 3711 6 0 0 0 1 transcriptional elongation regulator activity 3709 1 0 0 0 1 RNA polymerase III transcription factor activity 3708 3 0 0 0 1 retinoic acid receptor activity 3707 46 0 0 3 0.0513 steroid hormone receptor activity 3705 7 0 0 1 1 "RNA polymerase II transcription factor activity, enhancer binding" 3704 7 0 0 0 1 specific RNA polymerase II transcription factor activity 3702 68 0 0 5 0.0172 RNA polymerase II transcription factor activity 9008 2 0 0 0 1 DNA-methyltransferase activity 3701 1 0 0 0 1 RNA polymerase I transcription factor activity 3700 492 0 0 34 0 transcription factor activity 30492 2 0 0 0 1 hemoglobin binding 8599 2 0 0 0 1 "protein phosphatase type 1, regulator activity" 8598 2 0 0 1 0.3277 "protein phosphatase type 1, catalyst activity" 8597 1 0 0 1 0.18 "calcium-dependent protein serine/threonine phosphatase, regulator activity" 8580 3 0 0 0 1 cytoskeletal regulator activity 8574 1 0 0 0 1 plus-end-directed kinesin ATPase activity 8570 1 0 0 0 1 myosin ATPase activity 8569 2 0 0 0 1 minus-end-directed kinesin ATPase activity 16175 3 0 0 0 1 superoxide-generating NADPH oxidase activity 8565 131 0 0 27 0.4221 protein transporter activity 16174 3 0 0 0 1 NADPH oxidase activity 16165 7 0 0 0 1 lipoxygenase activity 8553 32 0 0 18 0 hydrogen-exporting ATPase activity 16160 4 0 0 0 1 amylase activity 4199 6 0 0 1 1 caspase activity 4198 10 0 0 2 0.6983 calpain activity 4197 49 0 0 12 0.2606 cysteine-type endopeptidase activity 4195 1 0 0 0 1 renin activity 4194 5 0 0 1 1 pepsin A activity 4193 1 0 0 0 1 cathepsin E activity 4192 1 0 0 1 0.18 cathepsin D activity 4190 7 0 0 1 1 aspartic-type endopeptidase activity 16151 1 0 0 0 1 nickel ion binding 4187 2 0 0 0 1 carboxypeptidase D activity 4186 2 0 0 0 1 carboxypeptidase C activity 4185 5 0 0 1 1 serine carboxypeptidase activity 30429 1 0 0 0 1 kynureninase activity 4183 1 0 0 0 1 carboxypeptidase H activity 4182 10 0 0 2 0.6983 carboxypeptidase A activity 4181 12 0 0 2 1 metallocarboxypeptidase activity 4180 13 0 0 1 0.4854 carboxypeptidase activity 8538 3 0 0 2 0.0855 proteasome activator activity 8536 7 0 0 0 1 RAN protein binding 8534 1 0 0 0 1 purine-specific oxidized base lesion DNA N-glycosylase activity 8533 10 0 0 0 1 astacin activity 4179 5 0 0 3 0.0437 membrane alanyl aminopeptidase activity 4177 23 0 0 8 0.0518 aminopeptidase activity 4176 2 0 0 0 1 ATP-dependent peptidase activity 4175 172 0 0 23 0.1307 endopeptidase activity 4174 1 0 0 0 1 electron-transferring-flavoprotein dehydrogenase activity 30414 61 0 0 16 0.0955 protease inhibitor activity 30412 1 0 0 0 1 formimidoyltetrahydrofolate cyclodeaminase activity 8528 77 0 0 2 0.0001 "peptide receptor activity, G-protein coupled" 8521 1 0 0 0 1 acetyl-CoA transporter activity 4167 1 0 0 0 1 dopachrome delta-isomerase activity 4165 1 0 0 0 1 dodecenoyl-CoA delta-isomerase activity 30409 1 0 0 0 1 glutamate formimidoyltransferase activity 4163 1 0 0 0 1 diphosphomevalonate decarboxylase activity 30407 1 0 0 0 1 formiminotransferase activity 8519 3 0 0 0 1 ammonium transporter activity 8518 2 0 0 0 1 reduced folate carrier activity 8517 4 0 0 0 1 folate transporter activity 8516 1 0 0 0 1 hexose uniporter activity 8514 19 0 0 0 1 organic anion transporter activity 8513 11 0 0 0 1 organic cation porter activity 8510 1 0 0 0 1 sodium:bicarbonate symporter activity 4158 1 0 0 0 1 dihydroorotate oxidase activity 4157 1 0 0 0 1 dihydropyrimidinase activity 4155 1 0 0 0 1 dihydropteridine reductase activity 4152 1 0 0 0 1 dihydroorotate dehydrogenase activity 8509 32 0 0 0 1 anion transporter activity 8508 3 0 0 0 1 bile acid:sodium symporter activity 8507 1 0 0 0 1 sodium:iodide symporter activity 8504 1 0 0 0 1 monoamine transporter activity 8502 3 0 0 0 1 melatonin receptor activity 4148 2 0 0 1 0.3277 dihydrolipoamide dehydrogenase activity 4146 1 0 0 0 1 dihydrofolate reductase activity 4145 1 0 0 1 0.18 diamine N-acetyltransferase activity 4144 1 0 0 0 1 diacylglycerol O-acyltransferase activity 4143 6 0 0 0 1 diacylglycerol kinase activity 4138 1 0 0 0 1 deoxyguanosine kinase activity 4137 1 0 0 0 1 deoxycytidine kinase activity 4129 12 0 0 9 0 cytochrome c oxidase activity 4128 1 0 0 1 0.0103 cytochrome b5 reductase activity 4126 2 0 0 0 1 cytidine deaminase activity 4123 1 0 0 0 1 cystathionine-gamma-lyase activity 4122 1 0 0 0 1 cystathione beta-synthase activity 4121 1 0 0 0 1 cystathionine beta-lyase activity 4119 1 0 0 0 1 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity 4118 1 0 0 0 1 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 4116 3 0 0 0 1 cGMP-specific phosphodiesterase activity 4115 5 0 0 1 1 cAMP-specific phosphodiesterase activity 4114 20 0 0 1 0.2368 "3',5'-cyclic-nucleotide phosphodiesterase activity" 4112 21 0 0 1 0.1547 cyclic-nucleotide phosphodiesterase activity 4111 4 0 0 2 0.1509 creatine kinase activity 4109 1 0 0 0 1 coproporphyrinogen oxidase activity 4108 1 0 0 0 1 citrate (SI)-synthase activity 4105 2 0 0 1 0.3277 choline-phosphate cytidylyltransferase activity 4104 3 0 0 0 1 cholinesterase activity 4103 2 0 0 0 1 choline kinase activity 4102 1 0 0 0 1 choline O-acetyltransferase activity 4100 1 0 0 0 1 chitin synthase activity 15662 58 0 0 24 0 P-type ATPase activity 3697 8 0 0 2 0.641 single-stranded DNA binding 3692 2 0 0 1 0.3277 left-handed Z-DNA binding 3690 8 0 0 0 1 double-stranded DNA binding 3689 5 0 0 0 1 DNA clamp loader activity 3688 1 0 0 0 1 DNA replication origin binding 3684 27 0 0 2 0.209 damaged DNA binding 3682 31 0 0 6 0.8153 chromatin binding 3680 1 0 0 0 1 AT DNA binding 15646 1 0 0 1 0.18 permease activity 15645 5 0 0 1 1 fatty-acid ligase activity 3678 12 0 0 2 1 DNA helicase activity 3677 925 0 0 124 0.0001 DNA binding 3676 1231 0 0 240 0.1385 nucleic acid binding 3674 5958 0 0 1076 0.7417 molecular_function 15631 36 0 0 7 0.8276 tubulin binding 42393 3 0 0 0 1 histone binding 42392 1 0 0 0 1 sphingosine-1-phosphate phosphatase activity 42379 26 0 0 4 1 chemokine receptor binding 30387 1 0 0 0 1 fructosamine-3-kinase activity 30380 1 0 0 0 1 interleukin-17E receptor binding 8499 4 0 0 0 1 "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" 8495 1 0 0 0 1 protoheme IX farnesyltransferase activity 8494 1 0 0 0 1 translation activator activity 30377 1 0 0 0 1 U-plasminogen activator receptor activity 30374 1 0 0 0 1 ligand-dependent nuclear receptor transcription co-activator activity 30371 1 0 0 0 1 translation repressor activity 8488 2 0 0 0 1 gamma-glutamyl carboxylase activity 8487 1 0 0 0 1 prenyl-dependent CAAX protease activity 8484 8 0 0 0 1 sulfuric ester hydrolase activity 8483 21 0 0 3 1 transaminase activity 8481 1 0 0 0 1 sphinganine kinase activity 30364 1 0 0 0 1 cleavage/polyadenylation specificity factor activity 30363 1 0 0 0 1 pre-mRNA cleavage factor activity 8478 1 0 0 1 0.18 pyridoxal kinase activity 16087 1 0 0 0 1 ecdysiostatic hormone activity 16086 1 0 0 0 1 allatostatin 16085 1 0 0 0 1 myoinhibitory hormone activity 8475 2 0 0 1 0.3277 procollagen-lysine 5-dioxygenase activity 8474 2 0 0 1 0.3277 palmitoyl-protein hydrolase activity 8470 1 0 0 0 1 isovaleryl-CoA dehydrogenase activity 30350 1 0 0 0 1 iron-responsive element binding 8466 1 0 0 0 1 glycogenin glucosyltransferase activity 8464 2 0 0 0 1 gamma-glutamyl hydrolase activity 8462 1 0 0 0 1 endopeptidase Clp activity 30345 1 0 0 0 1 structural constituent of tooth enamel 8458 1 0 0 0 1 carnitine O-octanoyltransferase activity 8455 1 0 0 0 1 "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" 8453 2 0 0 0 1 alanine-glyoxylate aminotransferase activity 8452 27 0 0 6 0.6137 RNA ligase activity 8450 1 0 0 0 1 O-sialoglycoprotein endopeptidase activity 42302 3 0 0 0 1 structural constituent of cuticle 4098 1 0 0 0 1 cerebroside-sulfatase activity 4096 1 0 0 1 0.18 catalase activity 4095 2 0 0 0 1 carnitine O-palmitoyltransferase activity 30338 1 0 0 1 0.18 CMP-N-acetylneuraminate monooxygenase activity 30337 1 0 0 0 1 DNA polymerase processivity factor activity 4092 1 0 0 0 1 carnitine O-acetyltransferase activity 4091 9 0 0 1 1 carboxylesterase activity 4090 2 0 0 1 0.0206 carbonyl reductase (NADPH) activity 30332 2 0 0 1 0.3277 cyclin binding 8449 1 0 0 0 1 N-acetylglucosamine-6-sulfatase activity 8444 1 0 0 0 1 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity 8443 5 0 0 3 0.0437 phosphofructokinase activity 8441 1 0 0 0 1 "3'(2'),5'-bisphosphate nucleotidase activity" 4089 6 0 0 1 1 carbonate dehydratase activity 4088 2 0 0 0 1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 4087 1 0 0 0 1 carbamoyl-phosphate synthase (ammonia) activity 4086 3 0 0 0 1 carbamoyl-phosphate synthase activity 4085 1 0 0 0 1 butyryl-CoA dehydrogenase activity 4084 3 0 0 1 0.4488 branched-chain amino acid aminotransferase activity 4083 1 0 0 1 0.18 bisphosphoglycerate phosphatase activity 4082 2 0 0 1 0.3277 bisphosphoglycerate mutase activity 4081 1 0 0 0 1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity 8437 1 0 0 0 1 thyrotropin-releasing hormone activity 8435 9 0 0 6 0.0017 anticoagulant activity 8434 1 0 0 0 1 vitamin D3 receptor activity 8431 1 0 0 0 1 tocopherol binding 8430 15 0 0 8 0.0021 selenium binding 4077 1 0 0 0 1 biotin-[acetyl-CoA-carboxylase] ligase activity 4075 2 0 0 0 1 biotin carboxylase activity 4074 2 0 0 1 0.3277 biliverdin reductase activity 4072 1 0 0 1 0.18 aspartate kinase activity 16034 1 0 0 0 1 maleylacetoacetate isomerase activity 8423 1 0 0 0 1 bleomycin hydrolase activity 4069 2 0 0 1 0.3277 aspartate aminotransferase activity 8420 8 0 0 3 0.1608 CTD phosphatase activity 4067 1 0 0 0 1 asparaginase activity 4066 1 0 0 0 1 asparagine synthase (glutamine-hydrolyzing) activity 4065 3 0 0 0 1 arylsulfatase activity 4064 3 0 0 0 1 arylesterase activity 4062 3 0 0 1 0.4488 aryl sulfotransferase activity 30305 1 0 0 0 1 heparanase activity 4060 3 0 0 1 0.4488 arylamine N-acetyltransferase activity 8419 1 0 0 0 1 RNA lariat debranching enzyme activity 8417 10 0 0 2 0.6983 fucosyltransferase activity 8415 57 0 0 14 0.2232 acyltransferase activity 8413 1 0 0 0 1 "7,8-dihydro-8-oxoguanine-triphosphatase activity" 8410 2 0 0 0 1 CoA-transferase activity 4058 1 0 0 0 1 aromatic-L-amino acid decarboxylase activity 4056 1 0 0 1 0.18 argininosuccinate lyase activity 4055 2 0 0 1 0.3277 argininosuccinate synthase activity 4053 2 0 0 0 1 arginase activity 4052 2 0 0 0 1 arachidonate 12-lipoxygenase activity 4051 1 0 0 0 1 arachidonate 5-lipoxygenase activity 4050 2 0 0 0 1 apyrase activity 16019 1 0 0 0 1 peptidoglycan recognition activity 8409 3 0 0 0 1 5'-3' exonuclease activity 8408 12 0 0 0 1 3'-5' exonuclease activity 4047 1 0 0 0 1 aminomethyltransferase activity 4046 2 0 0 0 1 aminoacylase activity 4042 1 0 0 0 1 amino acid N-acetyltransferase activity 4041 2 0 0 0 1 amine oxidase (flavin-containing) activity 4040 1 0 0 0 1 amidase activity 16005 1 0 0 0 1 phospholipase A2 activator activity 16004 1 0 0 0 1 phospholipase activator activity 19992 16 0 0 1 0.3337 diacylglycerol binding 16000 2 0 0 0 1 iota DNA polymerase activity 4037 1 0 0 0 1 allantoicase activity 4035 1 0 0 0 1 alkaline phosphatase activity 4033 1 0 0 1 0.18 aldo-keto reductase activity 4032 1 0 0 1 0.18 aldehyde reductase activity 4031 1 0 0 0 1 aldehyde oxidase activity 4030 2 0 0 2 0.0324 aldehyde dehydrogenase (NAD(P)+) activity 19986 2 0 0 0 1 "deoxycytidyl transferase activity, template dependent" 19984 2 0 0 0 1 sigma DNA polymerase activity 4029 7 0 0 6 0.0002 aldehyde dehydrogenase (NAD+) activity 4028 9 0 0 6 0.0017 aldehyde dehydrogenase activity 4026 2 0 0 0 1 alcohol O-acetyltransferase activity 4024 5 0 0 2 0.2224 "alcohol dehydrogenase activity, zinc-dependent" 4022 6 0 0 2 0.2957 alcohol dehydrogenase activity 4021 1 0 0 0 1 alanine aminotransferase activity 4020 1 0 0 0 1 adenylylsulfate kinase activity 4019 1 0 0 0 1 adenylosuccinate synthase activity 4018 1 0 0 1 0.18 adenylosuccinate lyase activity 4017 3 0 0 2 0.0855 adenylate kinase activity 4016 7 0 0 0 1 adenylate cyclase activity 4015 2 0 0 0 1 adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity 4014 1 0 0 0 1 adenosylmethionine decarboxylase activity 4013 2 0 0 2 0.0324 adenosylhomocysteinase activity 4012 1 0 0 0 1 phospholipid-translocating ATPase activity 19969 1 0 0 0 1 interleukin-10 binding 19968 1 0 0 0 1 "interleukin-1, Type II, blocking binding" 19967 10 0 0 0 1 "interleukin-1, Type I, activating binding" 19966 11 0 0 0 1 interleukin-1 binding 19965 31 0 0 1 0.0319 interleukin binding 19962 1 0 0 0 1 interferon-alpha/beta binding 19961 1 0 0 0 1 interferon binding 4009 45 0 0 10 0.4381 ATP-binding cassette (ABC) transporter activity 4008 2 0 0 0 1 copper-exporting ATPase activity 4005 7 0 0 2 0.6168 plasma membrane cation-transporting ATPase 4004 4 0 0 1 0.5481 ATP dependent RNA helicase activity 4003 8 0 0 2 0.641 ATP dependent DNA helicase activity 4001 1 0 0 0 1 adenosine kinase activity 4000 5 0 0 1 1 adenosine deaminase activity 19959 1 0 0 0 1 interleukin-8 binding 19958 5 0 0 0 1 C-X-C chemokine binding 19957 12 0 0 0 1 C-C chemokine binding 19956 18 0 0 0 1 chemokine binding 19955 49 0 0 1 0.0012 cytokine binding 19948 1 0 0 0 1 SUMO activating enzyme activity 15563 1 0 0 1 0.18 uptake permease activity 19914 1 0 0 0 1 "cyclin-dependent protein kinase activating kinase, regulator activity" 19912 1 0 0 0 1 cyclin-dependent protein kinase activating kinase activity 19911 1 0 0 0 1 structural constituent of myelin sheath 15559 1 0 0 0 1 multidrug efflux pump activity 19905 2 0 0 0 1 syntaxin binding 19904 6 0 0 3 0.0758 protein domain specific binding 19903 1 0 0 0 1 protein phosphatase binding 19902 1 0 0 0 1 phosphatase binding 19901 2 0 0 0 1 protein kinase binding 19900 2 0 0 0 1 kinase binding 42287 2 0 0 0 1 MHC protein binding 42285 1 0 0 0 1 xylosyltransferase activity 42277 88 0 0 4 0.0004 peptide binding 46625 1 0 0 0 1 sphingolipid binding 30296 1 0 0 0 1 protein tyrosine kinase activator activity 30295 2 0 0 0 1 protein kinase activator activity 8395 4 0 0 0 1 steroid hydroxylase activity 30276 3 0 0 0 1 clathrin binding 8387 1 0 0 0 1 steroid 7-alpha-hydroxylase activity 8384 1 0 0 0 1 IkappaB kinase activity 8383 1 0 0 0 1 manganese superoxide dismutase activity 8379 1 0 0 1 0.18 thioredoxin peroxidase activity 8378 15 0 0 0 1 galactosyltransferase activity 8376 6 0 0 4 0.0115 acetylgalactosaminyltransferase activity 8375 8 0 0 1 1 acetylglucosaminyltransferase activity 8374 13 0 0 1 0.4854 O-acyltransferase activity 8373 11 0 0 1 0.701 sialyltransferase activity 30250 1 0 0 0 1 guanylate cyclase activator activity 8369 78 0 0 17 0.3744 obsolete 30249 1 0 0 0 1 guanylate cyclase regulator activity 30247 1 0 0 0 1 polysaccharide binding 30246 43 0 0 0 1 carbohydrate binding 8353 1 0 0 0 1 [RNA-polymerase]-subunit kinase activity 30234 257 0 0 52 0.362 enzyme regulator activity 8349 1 0 0 0 1 MAP kinase kinase kinase kinase activity 30228 3 0 0 1 0.4488 lipoprotein receptor activity 8336 1 0 0 0 1 "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" 8332 2 0 0 0 1 low voltage-gated calcium channel activity 8331 4 0 0 0 1 high voltage-gated calcium channel activity 8327 1 0 0 0 1 methyl-CpG binding 8324 119 0 0 46 0 cation transporter activity 8321 1 0 0 0 1 Ral guanyl-nucleotide exchange factor activity 8318 9 0 0 3 0.2105 protein prenyltransferase activity 8313 1 0 0 0 1 gurken receptor activity 8312 1 0 0 1 0.18 7S RNA binding 8308 5 0 0 1 1 voltage-dependent ion-selective channel activity 8307 5 0 0 0 1 structural constituent of muscle 8301 4 0 0 0 1 DNA bending activity 19899 5 0 0 0 1 enzyme binding 19894 1 0 0 1 0.18 kinesin binding 19888 5 0 0 2 0.2224 protein phosphatase regulator activity 19887 41 0 0 9 0.5393 protein kinase regulator activity 19865 6 0 0 2 0.2957 immunoglobulin binding 19864 2 0 0 0 1 IgG binding 19863 4 0 0 2 0.1509 IgE binding 15499 1 0 0 0 1 formate transporter activity 15491 8 0 0 0 1 cation:cation antiporter activity 19843 5 0 0 3 0.0437 rRNA binding 19842 16 0 0 1 0.3337 vitamin binding 19841 4 0 0 0 1 retinol binding 19840 6 0 0 0 1 isoprenoid binding 15485 4 0 0 1 0.5481 cholesterol binding 15482 1 0 0 1 0.18 voltage-dependent anion channel porin activity 19838 31 0 0 6 0.8153 growth factor binding 19834 3 0 0 3 0.0058 phospholipase A2 inhibitor activity 19829 1 0 0 1 0.18 cation-transporting ATPase activity 19825 11 0 0 2 1 oxygen binding 15467 4 0 0 0 1 G-protein activated inward rectifier potassium channel activity 15464 1 0 0 0 1 acetylcholine receptor activity 15457 4 0 0 0 1 auxiliary transport protein activity 15450 9 0 0 2 0.6688 protein translocase activity 19807 1 0 0 0 1 aspartoacylase activity 15433 1 0 0 1 0.18 major histocompatibility peptide transporter activity 15427 1 0 0 1 0.18 ABC-type efflux porter activity 15406 1 0 0 1 0.18 ABC-type uptake permease activity 15405 111 0 0 35 0.0004 P-P-bond-hydrolysis-driven transporter activity 46527 6 0 0 2 0.2957 glucosyltransferase activity 42166 1 0 0 0 1 acetylcholine binding 42165 38 0 0 0 1 neurotransmitter binding 42162 3 0 0 0 1 telomeric DNA binding 42156 1 0 0 0 1 zinc-mediated transcriptional activator activity 8294 2 0 0 0 1 calcium/calmodulin-responsive adenylate cyclase activity 8289 78 0 0 19 0.1399 lipid binding 8281 2 0 0 0 1 sulfonylurea receptor activity 42134 1 0 0 0 1 rRNA primary transcript binding 42132 2 0 0 0 1 fructose-bisphosphatase activity 30169 3 0 0 1 0.4488 low-density lipoprotein binding 30161 1 0 0 1 0.18 calpain inhibitor activity 30160 1 0 0 0 1 GKAP/Homer scaffold activity 8276 8 0 0 0 1 protein methyltransferase activity 8273 2 0 0 0 1 "calcium, potassium:sodium antiporter activity" 8271 5 0 0 0 1 sulfate porter activity 42124 1 0 0 0 1 "1,3-beta-glucanosyltransferase activity" 8270 101 0 0 23 0.2388 zinc ion binding 42123 1 0 0 0 1 glucanosyltransferase activity 30159 4 0 0 0 1 receptor signaling complex scaffold protein activity 30158 1 0 0 0 1 peptide O-xylosyltransferase activity 30151 2 0 0 0 1 molybdenum ion binding 8269 1 0 0 0 1 JAK pathway signal transduction adaptor activity 8268 1 0 0 0 1 receptor signaling protein tyrosine kinase signaling protein activity 8265 1 0 0 0 1 Mo-molybdopterin cofactor sulfurase activity 8262 1 0 0 0 1 importin-alpha export receptor activity 8260 2 0 0 0 1 3-oxoacid CoA-transferase activity 30145 30 0 0 4 0.6381 manganese ion binding 8253 2 0 0 0 1 5'-nucleotidase activity 8252 3 0 0 0 1 nucleotidase activity 8251 1 0 0 0 1 tRNA specific adenosine deaminase activity 8248 30 0 0 16 0 pre-mRNA splicing factor activity 8246 7 0 0 1 1 electron transfer flavoprotein 8243 4 0 0 0 1 plasminogen activator activity 8242 2 0 0 0 1 omega peptidase activity 8241 2 0 0 0 1 peptidyl-dipeptidase activity 8240 1 0 0 0 1 tripeptidyl-peptidase activity 8239 6 0 0 2 0.2957 dipeptidyl-peptidase activity 8238 31 0 0 6 0.8153 exopeptidase activity 8237 105 0 0 15 0.3708 metallopeptidase activity 8236 100 0 0 8 0.0081 serine-type peptidase activity 8235 26 0 0 6 0.4496 metalloexopeptidase activity 8234 62 0 0 13 0.5088 cysteine-type peptidase activity 8233 309 0 0 59 0.596 peptidase activity 30116 1 0 0 0 1 glial cell line-derived neurotrophic factor receptor binding 8227 29 0 0 0 1 amine receptor activity 8225 1 0 0 0 1 Gram-negative antibacterial peptide activity 30106 2 0 0 1 0.3277 MHC class I receptor activity 8201 35 0 0 5 0.6653 heparin binding 19798 3 0 0 2 0.0855 procollagen-proline dioxygenase activity 19781 1 0 0 0 1 RUB1 activating enzyme activity 15399 135 0 0 51 0 primary active transporter activity 15390 1 0 0 0 1 purine-specific nucleoside:sodium symporter activity 15389 1 0 0 0 1 pyrimidine- and adenine-specific:sodium symporter activity 15385 3 0 0 0 1 sodium:hydrogen antiporter activity 15380 9 0 0 0 1 anion exchanger activity 19737 1 0 0 1 0.18 quinol:fumarate oxidoreductase activity 15379 1 0 0 0 1 potassium:chloride symporter activity 15377 7 0 0 1 1 cation:chloride symporter activity 15373 1 0 0 0 1 monovalent anion:sodium symporter activity 15370 13 0 0 1 0.4854 solute:sodium symporter activity 15368 5 0 0 0 1 calcium:cation antiporter activity 15362 1 0 0 0 1 high affinity sodium:dicarboxylate symporter activity 15359 6 0 0 1 0.0605 amino acid permease activity 15355 4 0 0 0 1 monocarboxylate porter activity 15354 6 0 0 0 1 polyspecific organic cation transporter activity 15334 1 0 0 0 1 high affinity oligopeptide transporter activity 15321 2 0 0 0 1 sodium-dependent phosphate transporter activity 15302 2 0 0 0 1 uncoupling protein activity 15301 9 0 0 0 1 anion:anion antiporter activity 15300 2 0 0 0 1 solute:solute antiporter activity 42084 1 0 0 0 1 5-methyltetrahydrofolate methyltransferase activity 42083 1 0 0 0 1 "5,10-methylenetetrahydrofolate-dependent methyltransferase activity" 42064 1 0 0 0 1 cell adhesion receptor regulator activity 42056 28 0 0 4 0.8062 chemoattractant activity 42054 1 0 0 0 1 histone methyltransferase activity 8199 4 0 0 2 0.1509 ferric iron binding 8195 2 0 0 0 1 phosphatidate phosphatase activity 8192 1 0 0 0 1 RNA guanylyltransferase activity 8191 4 0 0 1 0.5481 metalloendopeptidase inhibitor activity 42043 1 0 0 0 1 neurexin binding 8189 15 0 0 4 0.329 apoptosis inhibitor activity 8188 30 0 0 0 1 neuropeptide receptor activity 8187 1 0 0 0 1 poly-pyrimidine tract binding 8186 4 0 0 1 0.5481 RNA dependent ATPase activity 8184 1 0 0 0 1 glycogen phosphorylase activity 30060 2 0 0 2 0.0324 L-malate dehydrogenase activity 8177 1 0 0 1 0.18 succinate dehydrogenase (ubiquinone) activity 8174 1 0 0 0 1 mRNA methyltransferase activity 8173 3 0 0 2 0.0855 RNA methyltransferase activity 8172 6 0 0 0 1 S-methyltransferase activity 8171 3 0 0 1 0.4488 O-methyltransferase activity 8170 12 0 0 1 0.7058 N-methyltransferase activity 8168 54 0 0 7 0.4753 methyltransferase activity 8159 1 0 0 0 1 positive transcription elongation factor activity 8158 4 0 0 0 1 patched receptor activity 8157 1 0 0 0 1 protein phosphatase 1 binding 8146 20 0 0 1 0.2368 sulfotransferase activity 8144 4 0 0 1 0.5481 drug binding 8143 2 0 0 1 0.3277 poly(A) binding 8142 2 0 0 1 0.3277 oxysterol binding 30021 1 0 0 0 1 extracellular matrix structural constituent conferring compression resistance activity 30020 30 0 0 1 0.0314 extracellular matrix structural constituent conferring tensile strength activity 8139 1 0 0 0 1 nuclear localization sequence binding 8138 17 0 0 1 0.3391 protein tyrosine/serine/threonine phosphatase activity 8137 11 0 0 7 0.001 NADH dehydrogenase (ubiquinone) activity 8135 52 0 0 26 0 "translation factor activity, nucleic acid binding" 8134 68 0 0 11 0.8737 transcription factor binding 8133 3 0 0 0 1 collagenase activity 8132 1 0 0 0 1 pancreatic elastase activity 8131 4 0 0 0 1 amine oxidase activity 8130 1 0 0 0 1 neutrophil collagenase activity 8129 1 0 0 1 0.18 actinidain activity 8127 1 0 0 0 1 "quercetin 2,3-dioxygenase activity" 8124 1 0 0 0 1 4a-hydroxytetrahydrobiopterin dehydratase activity 8123 1 0 0 0 1 cholesterol 7-alpha-monooxygenase activity 8122 2 0 0 0 1 amine oxidase (copper-containing) activity 8120 2 0 0 1 0.3277 ceramide glucosyltransferase activity 8119 1 0 0 0 1 thiopurine S-methyltransferase activity 8117 1 0 0 1 0.18 sphinganine-1-phosphate aldolase activity 8116 1 0 0 0 1 prostaglandin-I synthase activity 8115 1 0 0 0 1 sarcosine oxidase activity 8114 1 0 0 1 0.0103 6-phosphogluconate 2-dehydrogenase activity 8113 1 0 0 0 1 protein-methionine-S-oxide reductase activity 8112 1 0 0 0 1 nicotinamide N-methyltransferase activity 8111 1 0 0 0 1 alpha-methylacyl-CoA racemase activity 8110 1 0 0 1 0.18 histidine aminotransferase activity 8109 1 0 0 0 1 "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity" 8108 1 0 0 0 1 UDP-glucose-hexose-1-phosphate uridylyltransferase activity 8107 2 0 0 1 0.3277 galactoside 2-alpha-L-fucosyltransferase activity 8106 2 0 0 1 0.0206 alcohol dehydrogenase (NADP+) activity 15299 2 0 0 0 1 solute:hydrogen antiporter activity 15298 2 0 0 0 1 solute:cation antiporter activity 15297 20 0 0 0 1 antiporter activity 15296 7 0 0 1 1 anion:cation symporter activity 15295 1 0 0 0 1 solute:hydrogen symporter activity 15294 17 0 0 1 0.3391 solute:cation symporter activity 15293 44 0 0 2 0.0166 symporter activity 15292 1 0 0 0 1 uniporter activity 15291 102 0 0 7 0.0017 porter activity 15290 103 0 0 7 0.0017 electrochemical potential-driven transporter activity 15288 13 0 0 2 1 porin activity 15285 11 0 0 0 1 connexon channel activity 15284 1 0 0 0 1 fructose uniporter activity 15280 4 0 0 2 0.1509 amiloride-sensitive sodium channel activity 15279 2 0 0 0 1 store-operated calcium channel activity 15278 1 0 0 0 1 calcium-release channel activity 15277 2 0 0 0 1 kainate selective glutamate receptor activity 15276 73 0 0 6 0.0306 ligand-gated ion channel activity 15272 1 0 0 0 1 ATP-activated inward rectifier potassium channel activity 15270 2 0 0 0 1 dihydropyridine-sensitive calcium channel activity 15269 6 0 0 0 1 calcium-activated potassium channel activity 15268 243 0 0 11 0 alpha-type channel activity 15267 247 0 0 11 0 channel/pore class transporter activity 15259 15 0 0 0 1 glutamate channel activity 15256 15 0 0 0 1 monocarboxylate channel activity 15250 9 0 0 1 1 water channel activity 15248 2 0 0 0 1 sterol transporter activity 15247 1 0 0 0 1 aminophospholipid transporter activity 15239 1 0 0 0 1 multidrug transporter activity 15238 1 0 0 0 1 drug transporter activity 15234 2 0 0 0 1 thiamin transporter activity 15232 1 0 0 0 1 heme transporter activity 15223 7 0 0 0 1 vitamin/cofactor transporter activity 15221 1 0 0 0 1 lipopolysaccharide transporter activity 15211 1 0 0 0 1 purine nucleoside transporter activity 15205 1 0 0 0 1 nucleobase transporter activity 15204 2 0 0 0 1 urea transporter activity 15203 24 0 0 3 0.6035 polyamine transporter activity 46332 1 0 0 0 1 SMAD binding 8097 2 0 0 1 0.3277 5S RNA binding 8095 1 0 0 0 1 "inositol-1,4,5-triphosphate receptor activity" 8094 19 0 0 2 0.5559 DNA dependent ATPase activity 8093 1 0 0 0 1 cytoskeletal adaptor activity 8092 173 0 0 34 0.5482 cytoskeletal protein binding 8083 103 0 0 3 0 growth factor activity 8081 40 0 0 3 0.0978 phosphoric diester hydrolase activity 8080 12 0 0 3 0.4625 N-acetyltransferase activity 8079 1 0 0 0 1 translation termination factor activity 8077 1 0 0 0 1 Hsp70/Hsp90 organizing protein activity 8075 1 0 0 0 1 receptor guanylate cyclase activity 8073 3 0 0 1 0.4488 ornithine decarboxylase inhibitor activity 8067 11 0 0 1 0.701 "metabotropic glutamate, GABA-B-like receptor activity" 8066 26 0 0 1 0.0706 glutamate receptor activity 8061 1 0 0 0 1 chitin binding 8060 1 0 0 0 1 ARF GTPase activator activity 8048 1 0 0 0 1 calcium sensitive guanylate cyclase activator activity 8047 69 0 0 11 0.754 enzyme activator activity 8046 7 0 0 0 1 axon guidance receptor activity 8042 2 0 0 0 1 iron-sulfur electron transfer carrier 8035 1 0 0 0 1 high-density lipoprotein binding 8034 5 0 0 1 1 lipoprotein binding 8028 8 0 0 0 1 monocarboxylic acid transporter activity 8027 1 0 0 0 1 sodium/excitatory glutamate symporter activity 8026 40 0 0 10 0.2988 ATP dependent helicase activity 8025 1 0 0 1 0.18 diazepam-binding inhibitor activity 8022 3 0 0 1 0.4488 protein C-terminus binding 8020 8 0 0 0 1 G-protein coupled photoreceptor activity 8017 34 0 0 6 1 microtubule binding 8014 7 0 0 1 1 calcium-dependent cell adhesion molecule activity 8013 2 0 0 0 1 beta-catenin binding 8012 1 0 0 0 1 structural constituent of adult cuticle (sensu Insecta) activity 8010 2 0 0 0 1 structural constituent of larval cuticle (sensu Insecta) activity 8009 26 0 0 4 1 chemokine activity 15198 6 0 0 0 1 oligopeptide transporter activity 15197 6 0 0 0 1 peptide transporter activity 15186 2 0 0 0 1 glutamine transporter activity 19531 1 0 0 0 1 oxalate transporter activity 15179 4 0 0 0 1 L-amino acid transporter activity 15175 3 0 0 0 1 neutral amino acid transporter activity 15174 4 0 0 0 1 basic amino acid transporter activity 15172 1 0 0 0 1 acidic amino acid transporter activity 15171 29 0 0 3 0.4645 amino acid transporter activity 15165 1 0 0 1 0.18 pyrimidine nucleotide sugar transporter activity 15159 1 0 0 0 1 polysaccharide transporter activity 15149 8 0 0 1 1 hexose transporter activity 15145 8 0 0 1 1 monosaccharide transporter activity 15144 16 0 0 3 1 carbohydrate transporter activity 15142 6 0 0 0 1 tricarboxylic acid transporter activity 15132 1 0 0 0 1 prostaglandin transporter activity 15125 3 0 0 0 1 bile acid transporter activity 15116 5 0 0 0 1 sulfate transporter activity 15114 1 0 0 0 1 phosphate transporter activity 15111 1 0 0 0 1 iodide transporter activity 15108 11 0 0 0 1 chloride transporter activity 15106 9 0 0 0 1 bicarbonate transporter activity 15105 1 0 0 0 1 arsenite transporter activity 15103 15 0 0 0 1 inorganic anion transporter activity 15101 16 0 0 0 1 organic cation transporter activity